| pubmed-article:12213907 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12213907 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:12213907 | lifeskim:mentions | umls-concept:C0205147 | lld:lifeskim |
| pubmed-article:12213907 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:12213907 | lifeskim:mentions | umls-concept:C0021655 | lld:lifeskim |
| pubmed-article:12213907 | lifeskim:mentions | umls-concept:C0205341 | lld:lifeskim |
| pubmed-article:12213907 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:12213907 | lifeskim:mentions | umls-concept:C0205216 | lld:lifeskim |
| pubmed-article:12213907 | lifeskim:mentions | umls-concept:C0003442 | lld:lifeskim |
| pubmed-article:12213907 | lifeskim:mentions | umls-concept:C1432227 | lld:lifeskim |
| pubmed-article:12213907 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:12213907 | pubmed:dateCreated | 2002-9-5 | lld:pubmed |
| pubmed-article:12213907 | pubmed:abstractText | Resistin is overexpressed in human adipose tissue of obese individuals and is likely to modulate insulin sensitivity. Resistin is, therefore, a candidate gene for insulin resistance. We searched for polymorphisms in the resistin gene by single strand conformation polymorphism and direct sequencing. An ATG triplet repeat in the 3'-untranslated region was identified and considered for association with insulin resistance. Three alleles were identified (allele 1: 8 repeats, allele frequency, 0.3%; allele 2: 7 repeats; allele frequency, 94.5%; allele 3: 6 repeats; allele frequency, 5.2%). Two hundred and three unrelated white Caucasian nondiabetic subjects from Sicily and 456 from the Gargano area (center east coast of Italy) were analyzed. Among Sicilians, subjects carrying allele 3 had a lower fasting insulin and insulin resistance index (homeostasis model assessment of insulin resistance; P < 0.001 for both) and glucose (P = 0.025) and insulin (P = 0.002) levels during the oral glucose tolerance test. In subjects from Gargano, those carrying allele 3 had lower fasting plasma glucose levels and serum triglycerides (P = 0.01 for both). When the 2 populations were analyzed together, subjects carrying allele 3 had lower fasting insulin levels (P < 0.005), homeostasis model assessment of insulin resistance (P < 0.005), and serum triglycerides (P = 0.01). In conclusion, our data suggest that subjects carrying allele 3 of the resistin gene are characterized by relatively high insulin sensitivity. | lld:pubmed |
| pubmed-article:12213907 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12213907 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12213907 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:12213907 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12213907 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12213907 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:12213907 | pubmed:issn | 0021-972X | lld:pubmed |
| pubmed-article:12213907 | pubmed:author | pubmed-author:DallapiccolaB... | lld:pubmed |
| pubmed-article:12213907 | pubmed:author | pubmed-author:VigneriRiccar... | lld:pubmed |
| pubmed-article:12213907 | pubmed:author | pubmed-author:PizzutiAntoni... | lld:pubmed |
| pubmed-article:12213907 | pubmed:author | pubmed-author:Di PaolaRosaR | lld:pubmed |
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| pubmed-article:12213907 | pubmed:author | pubmed-author:BozzaliMauraM | lld:pubmed |
| pubmed-article:12213907 | pubmed:author | pubmed-author:BarattaRobert... | lld:pubmed |
| pubmed-article:12213907 | pubmed:author | pubmed-author:TrischittaVin... | lld:pubmed |
| pubmed-article:12213907 | pubmed:author | pubmed-author:ArgiolasAless... | lld:pubmed |
| pubmed-article:12213907 | pubmed:author | pubmed-author:RauseoAnnaA | lld:pubmed |
| pubmed-article:12213907 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12213907 | pubmed:volume | 87 | lld:pubmed |
| pubmed-article:12213907 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12213907 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12213907 | pubmed:pagination | 4403-6 | lld:pubmed |
| pubmed-article:12213907 | pubmed:dateRevised | 2006-4-26 | lld:pubmed |
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| pubmed-article:12213907 | pubmed:meshHeading | pubmed-meshheading:12213907... | lld:pubmed |
| pubmed-article:12213907 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12213907 | pubmed:articleTitle | An ATG repeat in the 3'-untranslated region of the human resistin gene is associated with a decreased risk of insulin resistance. | lld:pubmed |
| pubmed-article:12213907 | pubmed:affiliation | Department of Experimental Medicine and Pathology, CSS-Mendel Institute, University La Sapienza, 00100 Rome, Italy. antipuzzuti@libero.it | lld:pubmed |
| pubmed-article:12213907 | pubmed:publicationType | Journal Article | lld:pubmed |
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