| pubmed-article:12213471 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12213471 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:12213471 | lifeskim:mentions | umls-concept:C1999216 | lld:lifeskim |
| pubmed-article:12213471 | lifeskim:mentions | umls-concept:C0332621 | lld:lifeskim |
| pubmed-article:12213471 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:12213471 | lifeskim:mentions | umls-concept:C0169424 | lld:lifeskim |
| pubmed-article:12213471 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:12213471 | pubmed:dateCreated | 2002-9-5 | lld:pubmed |
| pubmed-article:12213471 | pubmed:abstractText | A concise synthesis of the beta-amyloid(1-42 )aggregation inhibitor (-)-5,8-dihydroxy-3R-methyl-2R-(dipropylamino)-1,2,3,4-tetrahydronaphthalene [(-)-2] has been developed. The key step is a regio- and diastereoselective hydroboration-amination sequence to convert alkene into amine. Enantiomeric resolution was achieved by recrystallization of amine as the dibenzoyl-D-tartaric acid salt. Hydroquinone is a potent inhibitor of the fibrillar aggregation of beta-amyloid as determined in two different assay systems. | lld:pubmed |
| pubmed-article:12213471 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12213471 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12213471 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12213471 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12213471 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12213471 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12213471 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12213471 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12213471 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12213471 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12213471 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12213471 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12213471 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12213471 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12213471 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12213471 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:12213471 | pubmed:issn | 0968-0896 | lld:pubmed |
| pubmed-article:12213471 | pubmed:author | pubmed-author:HuoT LTL | lld:pubmed |
| pubmed-article:12213471 | pubmed:author | pubmed-author:ChenRobertR | lld:pubmed |
| pubmed-article:12213471 | pubmed:author | pubmed-author:ReitzAllen... | lld:pubmed |
| pubmed-article:12213471 | pubmed:author | pubmed-author:ParkerMichael... | lld:pubmed |
| pubmed-article:12213471 | pubmed:author | pubmed-author:ConwayKelly... | lld:pubmed |
| pubmed-article:12213471 | pubmed:author | pubmed-author:LeeDaniel H... | lld:pubmed |
| pubmed-article:12213471 | pubmed:author | pubmed-author:BoydRobert... | lld:pubmed |
| pubmed-article:12213471 | pubmed:author | pubmed-author:NorteySamuel... | lld:pubmed |
| pubmed-article:12213471 | pubmed:author | pubmed-author:RossTina MTM | lld:pubmed |
| pubmed-article:12213471 | pubmed:author | pubmed-author:ScottMalcolm... | lld:pubmed |
| pubmed-article:12213471 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12213471 | pubmed:volume | 10 | lld:pubmed |
| pubmed-article:12213471 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12213471 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12213471 | pubmed:pagination | 3565-9 | lld:pubmed |
| pubmed-article:12213471 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:12213471 | pubmed:meshHeading | pubmed-meshheading:12213471... | lld:pubmed |
| pubmed-article:12213471 | pubmed:meshHeading | pubmed-meshheading:12213471... | lld:pubmed |
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| pubmed-article:12213471 | pubmed:meshHeading | pubmed-meshheading:12213471... | lld:pubmed |
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| pubmed-article:12213471 | pubmed:meshHeading | pubmed-meshheading:12213471... | lld:pubmed |
| pubmed-article:12213471 | pubmed:meshHeading | pubmed-meshheading:12213471... | lld:pubmed |
| pubmed-article:12213471 | pubmed:meshHeading | pubmed-meshheading:12213471... | lld:pubmed |
| pubmed-article:12213471 | pubmed:meshHeading | pubmed-meshheading:12213471... | lld:pubmed |
| pubmed-article:12213471 | pubmed:meshHeading | pubmed-meshheading:12213471... | lld:pubmed |
| pubmed-article:12213471 | pubmed:meshHeading | pubmed-meshheading:12213471... | lld:pubmed |
| pubmed-article:12213471 | pubmed:meshHeading | pubmed-meshheading:12213471... | lld:pubmed |
| pubmed-article:12213471 | pubmed:meshHeading | pubmed-meshheading:12213471... | lld:pubmed |
| pubmed-article:12213471 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12213471 | pubmed:articleTitle | Synthesis of (-)-5,8-dihydroxy-3R-methyl-2R-(dipropylamino)-1,2,3,4-tetrahydronaphthalene: an inhibitor of beta-amyloid(1-42) aggregation. | lld:pubmed |
| pubmed-article:12213471 | pubmed:affiliation | Drug Discovery Division, Johnson and Johnson Pharmaceutical Research and Development, Spring House, PA 19477, USA. | lld:pubmed |
| pubmed-article:12213471 | pubmed:publicationType | Journal Article | lld:pubmed |
