| pubmed-article:12213257 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12213257 | lifeskim:mentions | umls-concept:C0001811 | lld:lifeskim |
| pubmed-article:12213257 | lifeskim:mentions | umls-concept:C0018557 | lld:lifeskim |
| pubmed-article:12213257 | lifeskim:mentions | umls-concept:C0006104 | lld:lifeskim |
| pubmed-article:12213257 | lifeskim:mentions | umls-concept:C0205145 | lld:lifeskim |
| pubmed-article:12213257 | lifeskim:mentions | umls-concept:C0036751 | lld:lifeskim |
| pubmed-article:12213257 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:12213257 | lifeskim:mentions | umls-concept:C0170657 | lld:lifeskim |
| pubmed-article:12213257 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:12213257 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:12213257 | pubmed:dateCreated | 2002-9-5 | lld:pubmed |
| pubmed-article:12213257 | pubmed:abstractText | Key proteins regulating serotonergic activity, specifically the serotonin transporter and 5-HT(1A) receptor, were examined in the midbrain raphe nuclei of young (3-4 months) and old (17-19 months) hamsters (N=7-10/group). An age-related decrease in the maximal density of serotonin transporter sites labelled with [(3)H]paroxetine (fmol/mg protein, Old: 396+/-13; Young: 487+/-27) was observed in the dorsal raphe nucleus (DRN) but not the median raphe nucleus (MRN), without affecting the affinity of [(3)H]paroxetine. In the DRN and MRN, the stimulation of [(35)S]GTP gamma S binding by the 5-HT(1A) receptor agonist 8-OH-DPAT, or the number of 5-HT(1A) receptor sites labeled with [(3)H] MPPF, was not different in old versus young animals. Thus in the DRN, aging decreased serotonin transporter sites without changing 5-HT(1A) receptor activation of G proteins or 5-HT(1A) receptor density. In the CA(1) region of hippocampus, 8-OH-DPAT-stimulated [(35)S]GTP gamma S binding was increased in the older animals (% above basal, Old: 141+/-21; Young: 81+/-17) without changing specific [(3)H] MPPF binding sites, suggesting that the capacity of 5-HT(1A) receptors to activate G proteins is enhanced. Aging also appears to enhance this capacity in the dentate gyrus, because this region exhibited a constant level of 8-OH-DPAT-stimulated [(35)S]GTP gamma S binding in spite of an age-related decrease in the number of [(3)H] MPPF binding sites (fmol/mg protein, Old: 203+/-21; Young: 429+/-51). | lld:pubmed |
| pubmed-article:12213257 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12213257 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12213257 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12213257 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12213257 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12213257 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12213257 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12213257 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12213257 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12213257 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12213257 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12213257 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12213257 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12213257 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12213257 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12213257 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12213257 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12213257 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12213257 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12213257 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12213257 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12213257 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12213257 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12213257 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12213257 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:12213257 | pubmed:issn | 0028-3908 | lld:pubmed |
| pubmed-article:12213257 | pubmed:author | pubmed-author:HenslerJulie... | lld:pubmed |
| pubmed-article:12213257 | pubmed:author | pubmed-author:DuncanMarilyn... | lld:pubmed |
| pubmed-article:12213257 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12213257 | pubmed:volume | 43 | lld:pubmed |
| pubmed-article:12213257 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12213257 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12213257 | pubmed:pagination | 36-44 | lld:pubmed |
| pubmed-article:12213257 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:12213257 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12213257 | pubmed:articleTitle | Aging alters in a region-specific manner serotonin transporter sites and 5-HT(1A) receptor-G protein interactions in hamster brain. | lld:pubmed |
| pubmed-article:12213257 | pubmed:affiliation | Department of Anatomy and Neurobiology, University of Kentucky Medical Center, 800 Rose Street, Lexington, KY 40536-0298, USA. mjdunc0@pop.uky.edu | lld:pubmed |
| pubmed-article:12213257 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12213257 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:12213257 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
