| pubmed-article:12210161 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12210161 | lifeskim:mentions | umls-concept:C1881977 | lld:lifeskim |
| pubmed-article:12210161 | lifeskim:mentions | umls-concept:C0242485 | lld:lifeskim |
| pubmed-article:12210161 | lifeskim:mentions | umls-concept:C1523052 | lld:lifeskim |
| pubmed-article:12210161 | lifeskim:mentions | umls-concept:C0872367 | lld:lifeskim |
| pubmed-article:12210161 | pubmed:issue | 16 | lld:pubmed |
| pubmed-article:12210161 | pubmed:dateCreated | 2002-9-4 | lld:pubmed |
| pubmed-article:12210161 | pubmed:abstractText | We examined the voltage-driven movement of single-stranded DNA molecules in a membrane channel or "nanopore". Using single channel recording methods and a statistical analysis of many single molecule events, we determined how voltage influences capture and translocation in the nanopore. We verified that the mean time between capture events follows a simple exponential distribution, whereas the translocation times follow a unique distribution that is partly Gaussian and partly exponential. Measurements of polymer sequence effects demonstrated that translocation duration is heavily influenced by specific or nonspecific purine-channel interactions. The single molecule approach we used revealed molecular interactions that can influence both capture rates and translocation velocities in a manner that enriches naive barrier crossing models. | lld:pubmed |
| pubmed-article:12210161 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12210161 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12210161 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12210161 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12210161 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12210161 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12210161 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:12210161 | pubmed:issn | 0173-0835 | lld:pubmed |
| pubmed-article:12210161 | pubmed:author | pubmed-author:MellerAmitA | lld:pubmed |
| pubmed-article:12210161 | pubmed:author | pubmed-author:BrantonDaniel... | lld:pubmed |
| pubmed-article:12210161 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12210161 | pubmed:volume | 23 | lld:pubmed |
| pubmed-article:12210161 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12210161 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12210161 | pubmed:pagination | 2583-91 | lld:pubmed |
| pubmed-article:12210161 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:12210161 | pubmed:meshHeading | pubmed-meshheading:12210161... | lld:pubmed |
| pubmed-article:12210161 | pubmed:meshHeading | pubmed-meshheading:12210161... | lld:pubmed |
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| pubmed-article:12210161 | pubmed:meshHeading | pubmed-meshheading:12210161... | lld:pubmed |
| pubmed-article:12210161 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12210161 | pubmed:articleTitle | Single molecule measurements of DNA transport through a nanopore. | lld:pubmed |
| pubmed-article:12210161 | pubmed:affiliation | The Rowland Institute for Science at Harvard, 100 Edwin H. Land Boulkevard, Cambridge, MA 02142, USA. meller@rowland.org. | lld:pubmed |
| pubmed-article:12210161 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12210161 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:12210161 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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