| pubmed-article:12207049 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12207049 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:12207049 | lifeskim:mentions | umls-concept:C0021757 | lld:lifeskim |
| pubmed-article:12207049 | lifeskim:mentions | umls-concept:C0005953 | lld:lifeskim |
| pubmed-article:12207049 | lifeskim:mentions | umls-concept:C0205160 | lld:lifeskim |
| pubmed-article:12207049 | lifeskim:mentions | umls-concept:C1704735 | lld:lifeskim |
| pubmed-article:12207049 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:12207049 | pubmed:dateCreated | 2002-9-3 | lld:pubmed |
| pubmed-article:12207049 | pubmed:abstractText | We have reported that an inhibitor of interleukin-3 (NIL-3) is produced from murine bone marrow cells in response to excess stimulation of interleukin-3. In this report, we attempted the purification of the NIL-3 activity from bone marrow culture supernatant in the presence of interleukin-3. The purified NIL-3 activity was a protein with relative molecular weight of 54.5 kDa (SDS-PAGE), which inhibited the growth of IL-3 dependent DA-1 cell growth in a dose dependent manner. The N-terminal amino acid sequence of purified NIL-3 activity was determined to be homologous to beta-2 glycoprotein I (apolipoprotein H: APO-H). The gene expression of APO-H was detected by nested-PCR in STIL-3 C5-CM stimulated total bone marrow cells and STIL-3 C5-CM stimulated bone marrow fraction 2 (Fr. 2) which has been reported as a hematopoietic stem cell rich fraction. These observations indicate the possibility that the APO-H is the NIL-3 which was produced from bone marrow cells in response to excess IL-3 stimuli. | lld:pubmed |
| pubmed-article:12207049 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12207049 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12207049 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12207049 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12207049 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12207049 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12207049 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12207049 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12207049 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12207049 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:12207049 | pubmed:issn | 0386-7196 | lld:pubmed |
| pubmed-article:12207049 | pubmed:author | pubmed-author:YasuhiroAdach... | lld:pubmed |
| pubmed-article:12207049 | pubmed:author | pubmed-author:SugimotoKenki... | lld:pubmed |
| pubmed-article:12207049 | pubmed:author | pubmed-author:SatoAsako KAK | lld:pubmed |
| pubmed-article:12207049 | pubmed:author | pubmed-author:MoriKazuhiro... | lld:pubmed |
| pubmed-article:12207049 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12207049 | pubmed:volume | 27 | lld:pubmed |
| pubmed-article:12207049 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12207049 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12207049 | pubmed:pagination | 81-9 | lld:pubmed |
| pubmed-article:12207049 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:12207049 | pubmed:meshHeading | pubmed-meshheading:12207049... | lld:pubmed |
| pubmed-article:12207049 | pubmed:meshHeading | pubmed-meshheading:12207049... | lld:pubmed |
| pubmed-article:12207049 | pubmed:meshHeading | pubmed-meshheading:12207049... | lld:pubmed |
| pubmed-article:12207049 | pubmed:meshHeading | pubmed-meshheading:12207049... | lld:pubmed |
| pubmed-article:12207049 | pubmed:meshHeading | pubmed-meshheading:12207049... | lld:pubmed |
| pubmed-article:12207049 | pubmed:meshHeading | pubmed-meshheading:12207049... | lld:pubmed |
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| pubmed-article:12207049 | pubmed:meshHeading | pubmed-meshheading:12207049... | lld:pubmed |
| pubmed-article:12207049 | pubmed:meshHeading | pubmed-meshheading:12207049... | lld:pubmed |
| pubmed-article:12207049 | pubmed:meshHeading | pubmed-meshheading:12207049... | lld:pubmed |
| pubmed-article:12207049 | pubmed:meshHeading | pubmed-meshheading:12207049... | lld:pubmed |
| pubmed-article:12207049 | pubmed:meshHeading | pubmed-meshheading:12207049... | lld:pubmed |
| pubmed-article:12207049 | pubmed:meshHeading | pubmed-meshheading:12207049... | lld:pubmed |
| pubmed-article:12207049 | pubmed:meshHeading | pubmed-meshheading:12207049... | lld:pubmed |
| pubmed-article:12207049 | pubmed:meshHeading | pubmed-meshheading:12207049... | lld:pubmed |
| pubmed-article:12207049 | pubmed:meshHeading | pubmed-meshheading:12207049... | lld:pubmed |
| pubmed-article:12207049 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12207049 | pubmed:articleTitle | Identification of negative regulator of interleukin-3 (NIL-3) in bone marrow. | lld:pubmed |
| pubmed-article:12207049 | pubmed:affiliation | Department of Cell Science, Graduate School of Science and Technology, Nigata University, Japan. adachiy@yamaguchi-u.ac.jp | lld:pubmed |
| pubmed-article:12207049 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12207049 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
