| pubmed-article:12200137 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12200137 | lifeskim:mentions | umls-concept:C0022688 | lld:lifeskim |
| pubmed-article:12200137 | lifeskim:mentions | umls-concept:C0034819 | lld:lifeskim |
| pubmed-article:12200137 | lifeskim:mentions | umls-concept:C1514762 | lld:lifeskim |
| pubmed-article:12200137 | lifeskim:mentions | umls-concept:C0599697 | lld:lifeskim |
| pubmed-article:12200137 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:12200137 | pubmed:dateCreated | 2002-8-29 | lld:pubmed |
| pubmed-article:12200137 | pubmed:abstractText | Interleukin-2 induces heterodimerization of the IL-2 receptor beta and gamma subunits. This study addresses a role of the Shb adapter protein in IL-2 receptor signaling in T and NK cells. The IL-2Rbeta and gamma chains were found to co-immunoprecipitate with Shb, when each alone was co-expressed with Shb in COS cells. Using fusion proteins, the Shb SH2 domain was found to associate in a phosphotyrosine-dependent manner with the IL-2 receptor beta and gamma subunits upon IL-2 stimulation in primary T cells and the NK cell line NK-92. The main binding site of the Shb SH2 domain was phosphorylated Tyr-510 in the IL-2Rbeta chain. Shb was also phosphorylated upon IL-2 stimulation when overexpressed together with IL-2Rbeta (in pre-B cells, which express the gamma chain constitutively). These cells were also less apoptotic in the presence of IL-2 than cells overexpressing a mutant Shb (with a defect SH2 domain) or cells expressing a mutant IL-2Rbeta, with the Shb binding sites mutated to phenylalanine (Y392F, Y510F). JAK1 and JAK3 were also found to associate with Shb, but in contrast to the Shb-IL-2 receptor association, JAK1 and 3 appear to associate with the proline-rich regions of Shb. In conclusion, Shb links the IL-2 receptor to other signaling proteins and mediates the regulation of apoptosis in the presence of IL-2. | lld:pubmed |
| pubmed-article:12200137 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12200137 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12200137 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12200137 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12200137 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:12200137 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:12200137 | pubmed:author | pubmed-author:LindholmCecil... | lld:pubmed |
| pubmed-article:12200137 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12200137 | pubmed:day | 30 | lld:pubmed |
| pubmed-article:12200137 | pubmed:volume | 296 | lld:pubmed |
| pubmed-article:12200137 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12200137 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12200137 | pubmed:pagination | 929-36 | lld:pubmed |
| pubmed-article:12200137 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:12200137 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12200137 | pubmed:articleTitle | IL-2 receptor signaling through the Shb adapter protein in T and NK cells. | lld:pubmed |
| pubmed-article:12200137 | pubmed:affiliation | Department of Medical Cell Biology, Uppsala University, Biomedicum, Box 571, S-75123 Uppsala, Sweden. Cecilia.Lindholm@medcellbiol.uu.se | lld:pubmed |
| pubmed-article:12200137 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12200137 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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