| pubmed-article:12196292 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12196292 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
| pubmed-article:12196292 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
| pubmed-article:12196292 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:12196292 | lifeskim:mentions | umls-concept:C0011306 | lld:lifeskim |
| pubmed-article:12196292 | lifeskim:mentions | umls-concept:C0003320 | lld:lifeskim |
| pubmed-article:12196292 | lifeskim:mentions | umls-concept:C0023395 | lld:lifeskim |
| pubmed-article:12196292 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
| pubmed-article:12196292 | lifeskim:mentions | umls-concept:C1334145 | lld:lifeskim |
| pubmed-article:12196292 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
| pubmed-article:12196292 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
| pubmed-article:12196292 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:12196292 | lifeskim:mentions | umls-concept:C0205228 | lld:lifeskim |
| pubmed-article:12196292 | lifeskim:mentions | umls-concept:C0333668 | lld:lifeskim |
| pubmed-article:12196292 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:12196292 | pubmed:dateCreated | 2002-8-28 | lld:pubmed |
| pubmed-article:12196292 | pubmed:abstractText | Cytotoxic T lymphocytes (CTL) respond to antigenic peptides presented on MHC class I molecules. On most cells, these peptides are exclusively of endogenous, cytosolic origin. Bone marrow-derived antigen-presenting cells, however, harbor a unique pathway for MHC I presentation of exogenous antigens. This mechanism permits cross-presentation of pathogen-infected cells and the priming of CTL responses against intracellular microbial infections. Here, we report a novel diphtheria toxin-based system that allows the inducible, short-term ablation of dendritic cells (DC) in vivo. We show that in vivo DC are required to cross-prime CTL precursors. Our results thus define a unique in vivo role of DC, i.e., the sensitization of the immune system for cell-associated antigens. DC-depleted mice fail to mount CTL responses to infection with the intracellular bacterium Listeria monocytogenes and the rodent malaria parasite Plasmodium yoelii. | lld:pubmed |
| pubmed-article:12196292 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12196292 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12196292 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12196292 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12196292 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12196292 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12196292 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12196292 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12196292 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12196292 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12196292 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12196292 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:12196292 | pubmed:issn | 1074-7613 | lld:pubmed |
| pubmed-article:12196292 | pubmed:author | pubmed-author:LittmanDan... | lld:pubmed |
| pubmed-article:12196292 | pubmed:author | pubmed-author:PamerEric GEG | lld:pubmed |
| pubmed-article:12196292 | pubmed:author | pubmed-author:UnutmazDeryaD | lld:pubmed |
| pubmed-article:12196292 | pubmed:author | pubmed-author:SanoGen-Ichir... | lld:pubmed |
| pubmed-article:12196292 | pubmed:author | pubmed-author:ZavalaFidelF | lld:pubmed |
| pubmed-article:12196292 | pubmed:author | pubmed-author:WongPhillipP | lld:pubmed |
| pubmed-article:12196292 | pubmed:author | pubmed-author:LangRichard... | lld:pubmed |
| pubmed-article:12196292 | pubmed:author | pubmed-author:JungSteffenS | lld:pubmed |
| pubmed-article:12196292 | pubmed:author | pubmed-author:De los... | lld:pubmed |
| pubmed-article:12196292 | pubmed:author | pubmed-author:SparwasserTim... | lld:pubmed |
| pubmed-article:12196292 | pubmed:author | pubmed-author:WuShengjiS | lld:pubmed |
| pubmed-article:12196292 | pubmed:author | pubmed-author:VuthooriSriS | lld:pubmed |
| pubmed-article:12196292 | pubmed:author | pubmed-author:KoKyungK | lld:pubmed |
| pubmed-article:12196292 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12196292 | pubmed:volume | 17 | lld:pubmed |
| pubmed-article:12196292 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12196292 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12196292 | pubmed:pagination | 211-20 | lld:pubmed |
| pubmed-article:12196292 | pubmed:dateRevised | 2011-1-25 | lld:pubmed |
| pubmed-article:12196292 | pubmed:meshHeading | pubmed-meshheading:12196292... | lld:pubmed |
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| pubmed-article:12196292 | pubmed:meshHeading | pubmed-meshheading:12196292... | lld:pubmed |
| pubmed-article:12196292 | pubmed:meshHeading | pubmed-meshheading:12196292... | lld:pubmed |
| pubmed-article:12196292 | pubmed:meshHeading | pubmed-meshheading:12196292... | lld:pubmed |
| pubmed-article:12196292 | pubmed:meshHeading | pubmed-meshheading:12196292... | lld:pubmed |
| pubmed-article:12196292 | pubmed:meshHeading | pubmed-meshheading:12196292... | lld:pubmed |
| pubmed-article:12196292 | pubmed:meshHeading | pubmed-meshheading:12196292... | lld:pubmed |
| pubmed-article:12196292 | pubmed:meshHeading | pubmed-meshheading:12196292... | lld:pubmed |
| pubmed-article:12196292 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12196292 | pubmed:articleTitle | In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens. | lld:pubmed |
| pubmed-article:12196292 | pubmed:affiliation | Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York 10016, USA. s.jung@weizmann.ac.il | lld:pubmed |
| pubmed-article:12196292 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12196292 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12196292 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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