| pubmed-article:12194297 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12194297 | lifeskim:mentions | umls-concept:C1522449 | lld:lifeskim |
| pubmed-article:12194297 | lifeskim:mentions | umls-concept:C0205252 | lld:lifeskim |
| pubmed-article:12194297 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:12194297 | lifeskim:mentions | umls-concept:C0007589 | lld:lifeskim |
| pubmed-article:12194297 | lifeskim:mentions | umls-concept:C0022023 | lld:lifeskim |
| pubmed-article:12194297 | lifeskim:mentions | umls-concept:C0205225 | lld:lifeskim |
| pubmed-article:12194297 | lifeskim:mentions | umls-concept:C1511938 | lld:lifeskim |
| pubmed-article:12194297 | pubmed:issue | 1-4 | lld:pubmed |
| pubmed-article:12194297 | pubmed:dateCreated | 2002-8-26 | lld:pubmed |
| pubmed-article:12194297 | pubmed:abstractText | The ureter primary explant technique was developed to study bystander effects under in vivo like conditions where stem and differentiated cells are present. Irradiation was performed with a 3He2+ charged particle microbeam available at the Gray Cancer Institute, with high (approximately 2 microns) precision. Tissue sections from porcine ureters were pre-irradiated with the microbeam at a single location with 10 3He2+ particles (5 MeV; LET 70 keV.micron-1). After irradiation, the tissue section was incubated for 7 days, thus allowing the explant outgrowth to form. Total cellular damage (total fraction of micronucleated and apoptotic cells) was measured according to morphological criteria. Apoptosis was also assessed using a 3'-OH DNA end-labelling technique. Premature differentiation was estimated using antibodies to uroplakin III, a specific marker of terminal urothelial differentiation. Results of our experiments demonstrated a significant bystander-induced differentiation and a less significant increase in apoptotic and micronucleated cells. A hypothesis based on the protective nature of the bystander effect is proposed. | lld:pubmed |
| pubmed-article:12194297 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12194297 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12194297 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12194297 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12194297 | pubmed:issn | 0144-8420 | lld:pubmed |
| pubmed-article:12194297 | pubmed:author | pubmed-author:MichaelB DBD | lld:pubmed |
| pubmed-article:12194297 | pubmed:author | pubmed-author:MothersillCC | lld:pubmed |
| pubmed-article:12194297 | pubmed:author | pubmed-author:PriseK MKM | lld:pubmed |
| pubmed-article:12194297 | pubmed:author | pubmed-author:FolkardMM | lld:pubmed |
| pubmed-article:12194297 | pubmed:author | pubmed-author:BelyakovO VOV | lld:pubmed |
| pubmed-article:12194297 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12194297 | pubmed:volume | 99 | lld:pubmed |
| pubmed-article:12194297 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12194297 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12194297 | pubmed:pagination | 249-51 | lld:pubmed |
| pubmed-article:12194297 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:12194297 | pubmed:meshHeading | pubmed-meshheading:12194297... | lld:pubmed |
| pubmed-article:12194297 | pubmed:meshHeading | pubmed-meshheading:12194297... | lld:pubmed |
| pubmed-article:12194297 | pubmed:meshHeading | pubmed-meshheading:12194297... | lld:pubmed |
| pubmed-article:12194297 | pubmed:meshHeading | pubmed-meshheading:12194297... | lld:pubmed |
| pubmed-article:12194297 | pubmed:meshHeading | pubmed-meshheading:12194297... | lld:pubmed |
| pubmed-article:12194297 | pubmed:meshHeading | pubmed-meshheading:12194297... | lld:pubmed |
| pubmed-article:12194297 | pubmed:meshHeading | pubmed-meshheading:12194297... | lld:pubmed |
| pubmed-article:12194297 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12194297 | pubmed:articleTitle | Bystander-induced apoptosis and premature differentiation in primary urothelial explants after charged particle microbeam irradiation. | lld:pubmed |
| pubmed-article:12194297 | pubmed:affiliation | Gray Cancer Institute, PO Box 100, Mount Vernon Hospital, Northwood, Middlesex, HA6 2JR, UK. belyakov@gei.ac.uk | lld:pubmed |
| pubmed-article:12194297 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12194297 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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