| pubmed-article:12186894 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12186894 | lifeskim:mentions | umls-concept:C0019682 | lld:lifeskim |
| pubmed-article:12186894 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:12186894 | lifeskim:mentions | umls-concept:C0031166 | lld:lifeskim |
| pubmed-article:12186894 | lifeskim:mentions | umls-concept:C0695347 | lld:lifeskim |
| pubmed-article:12186894 | pubmed:issue | 18 | lld:pubmed |
| pubmed-article:12186894 | pubmed:dateCreated | 2002-8-20 | lld:pubmed |
| pubmed-article:12186894 | pubmed:abstractText | The metabolic and cell cycle status of primary T lymphocytes conditions their susceptibility to human immunodeficiency virus (HIV) and HIV-derived vectors. While in fully quiescent T lymphocytes the reverse transcription and nuclear import of these retroelements are impaired, leading to an abortive infection, various stimuli can induce a state of virus permissiveness. Here, we studied the modalities by which interleukin-7 (IL-7), an important controller of T-cell homeostasis, exerts this effect. IL-7-exposed cord blood T lymphocytes proliferated and were efficiently transduced by HIV-derived vectors. In contrast, similarly treated adult peripheral blood (PB) T lymphocytes failed to divide, and only a subset of these cells became infectible. HIV-resistant and -sensitive subsets of IL-7-treated PB T lymphocytes differed in cell cycle status but not in naïve, memory, or activation phenotypes. Nuclear factor of activated T cells was not induced by IL-7, and cyclosporine did not prevent HIV-mediated gene transfer. Furthermore, the phosphatidylinositol 3-kinase (PI3K) inhibitor wortmannin blocked IL-7-induced cell survival and Bcl-2 synthesis but had no effect on the acquisition of HIV susceptibility, suggesting that IL-7-induced HIV type 1 permissiveness is not mediated by the PI-3 K pathway and that, perhaps, the Jak/STAT5 pathway, the other known mediator of IL-7-triggered signaling in T cells, governs this process. | lld:pubmed |
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| pubmed-article:12186894 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12186894 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12186894 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12186894 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12186894 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:12186894 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:12186894 | pubmed:author | pubmed-author:TronoDidierD | lld:pubmed |
| pubmed-article:12186894 | pubmed:author | pubmed-author:Ducrey-Rundqu... | lld:pubmed |
| pubmed-article:12186894 | pubmed:author | pubmed-author:GuyaderMireil... | lld:pubmed |
| pubmed-article:12186894 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12186894 | pubmed:volume | 76 | lld:pubmed |
| pubmed-article:12186894 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12186894 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12186894 | pubmed:pagination | 9103-11 | lld:pubmed |
| pubmed-article:12186894 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:12186894 | pubmed:meshHeading | pubmed-meshheading:12186894... | lld:pubmed |
| pubmed-article:12186894 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12186894 | pubmed:articleTitle | Modalities of interleukin-7-induced human immunodeficiency virus permissiveness in quiescent T lymphocytes. | lld:pubmed |
| pubmed-article:12186894 | pubmed:affiliation | Department of Genetics and Microbiology, Faculty of Medicine, University of Geneva, Geneva, Switzerland. | lld:pubmed |
| pubmed-article:12186894 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12186894 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12186894 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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