Linked Life Data

12182870

Source:http://linkedlifedata.com/resource/pubmed/id/12182870

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pubmed-article:12182870pubmed:abstractTextThe introduction of a functionalised amido substituent into a series of 1-(biphenylmethylacetamido)-pyrimidones has given a series of inhibitors of recombinant lipoprotein-associated phospholipase A(2) with sub-nanomolar potency and very encouraging developability properties. Diethylaminoethyl derivative 32, SB-435495, was selected for progression to man.lld:pubmed
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pubmed-article:12182870pubmed:articleTitleThe discovery of SB-435495. A potent, orally active inhibitor of lipoprotein-associated phospholipase A(2) for evaluation in man.lld:pubmed
pubmed-article:12182870pubmed:affiliationGlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, SG1 2NY, Stevenage, UK.lld:pubmed
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