| pubmed-article:12182453 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12182453 | lifeskim:mentions | umls-concept:C1337103 | lld:lifeskim |
| pubmed-article:12182453 | lifeskim:mentions | umls-concept:C1705388 | lld:lifeskim |
| pubmed-article:12182453 | lifeskim:mentions | umls-concept:C0149615 | lld:lifeskim |
| pubmed-article:12182453 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:12182453 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:12182453 | lifeskim:mentions | umls-concept:C1334309 | lld:lifeskim |
| pubmed-article:12182453 | lifeskim:mentions | umls-concept:C1709059 | lld:lifeskim |
| pubmed-article:12182453 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:12182453 | lifeskim:mentions | umls-concept:C0686907 | lld:lifeskim |
| pubmed-article:12182453 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:12182453 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:12182453 | pubmed:dateCreated | 2002-8-16 | lld:pubmed |
| pubmed-article:12182453 | pubmed:abstractText | Ly49 antigens, interacting with MHC class I molecules, enable NK cells to distinguish "self" from "non-self". Here, we investigated the activating receptor Ly49 D after allogeneic bone marrow transplantation (BMT). After transplantation of B6 bone marrow (BM) into BALB/c recipients we observed a significant reduction of Ly49 D+ NK cells and a decreased density of expression. We found a nonstochastic distribution of Ly49 D with Ly49 G2. In contrast to reduced coexpression with Ly49 A, a constant rate of Ly49 G2 on Ly49 D+ NK cells was observed in allogeneic chimeras. Cytotoxicity was reduced during the first two months after BMT After this time allogeneic chimeras showed tolerance against host-specific targets. We conclude that NK cells are able to shape their Lys49 repertoire fitting to a new environment after allogeneic BMT. This alteration seems to depend on the presence of new corresponding MHC class I molecules resulting in downregulation of respective receptors on donor cells. Analysing coexpression of Ly49 D and Ly49 G2, we found a relationship between these two receptors, showing a distinct effect after allogeneic BMT. Functional data indicate that a time of reduced NK cell cytotoxicity after BMT is followed by in vitro tolerance of allogeneic chimeras. | lld:pubmed |
| pubmed-article:12182453 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12182453 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12182453 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12182453 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12182453 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12182453 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12182453 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12182453 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:12182453 | pubmed:issn | 0171-2985 | lld:pubmed |
| pubmed-article:12182453 | pubmed:author | pubmed-author:Meyer-OlsonDi... | lld:pubmed |
| pubmed-article:12182453 | pubmed:author | pubmed-author:Zielinska-Sko... | lld:pubmed |
| pubmed-article:12182453 | pubmed:author | pubmed-author:KortenSimoneS | lld:pubmed |
| pubmed-article:12182453 | pubmed:author | pubmed-author:WilkEstherE | lld:pubmed |
| pubmed-article:12182453 | pubmed:author | pubmed-author:SchmidtReinho... | lld:pubmed |
| pubmed-article:12182453 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12182453 | pubmed:volume | 205 | lld:pubmed |
| pubmed-article:12182453 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12182453 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12182453 | pubmed:pagination | 267-81 | lld:pubmed |
| pubmed-article:12182453 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:12182453 | pubmed:meshHeading | pubmed-meshheading:12182453... | lld:pubmed |
| pubmed-article:12182453 | pubmed:meshHeading | pubmed-meshheading:12182453... | lld:pubmed |
| pubmed-article:12182453 | pubmed:meshHeading | pubmed-meshheading:12182453... | lld:pubmed |
| pubmed-article:12182453 | pubmed:meshHeading | pubmed-meshheading:12182453... | lld:pubmed |
| pubmed-article:12182453 | pubmed:meshHeading | pubmed-meshheading:12182453... | lld:pubmed |
| pubmed-article:12182453 | pubmed:meshHeading | pubmed-meshheading:12182453... | lld:pubmed |
| pubmed-article:12182453 | pubmed:meshHeading | pubmed-meshheading:12182453... | lld:pubmed |
| pubmed-article:12182453 | pubmed:meshHeading | pubmed-meshheading:12182453... | lld:pubmed |
| pubmed-article:12182453 | pubmed:meshHeading | pubmed-meshheading:12182453... | lld:pubmed |
| pubmed-article:12182453 | pubmed:meshHeading | pubmed-meshheading:12182453... | lld:pubmed |
| pubmed-article:12182453 | pubmed:meshHeading | pubmed-meshheading:12182453... | lld:pubmed |
| pubmed-article:12182453 | pubmed:meshHeading | pubmed-meshheading:12182453... | lld:pubmed |
| pubmed-article:12182453 | pubmed:meshHeading | pubmed-meshheading:12182453... | lld:pubmed |
| pubmed-article:12182453 | pubmed:meshHeading | pubmed-meshheading:12182453... | lld:pubmed |
| pubmed-article:12182453 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12182453 | pubmed:articleTitle | Modulation of Ly49 D expression after allogeneic bone marrow transplantation and functional consequences. | lld:pubmed |
| pubmed-article:12182453 | pubmed:affiliation | Abteilung Klinische Immunologie, Medizinische Hochschule Hannover, Germany. | lld:pubmed |
| pubmed-article:12182453 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12182453 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
