| pubmed-article:12175937 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12175937 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:12175937 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:12175937 | lifeskim:mentions | umls-concept:C0008838 | lld:lifeskim |
| pubmed-article:12175937 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:12175937 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:12175937 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:12175937 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:12175937 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:12175937 | pubmed:dateCreated | 2002-8-14 | lld:pubmed |
| pubmed-article:12175937 | pubmed:abstractText | Cisplatin is an effective agent for the treatment of testicular cancer. In the present study with mouse testicular teratocarcinoma cell extracts, we observed a deficiency in nucleotide excision repair (NER) of a DNA probe bearing a cisplatin 1,2-d(GpG) intrastrand cross-link. In contrast, repair of the cisplatin 1,3-d(GpTpG) intrastrand cross-link was still active in these cell extracts. A current working hypothesis is that complexes of HMG-domain proteins with the major cisplatin 1,2-intrastrand cross-links could enhance cisplatin cytotoxicity by blocking repair of these lesions on the genome. The family of HMG-domain proteins include a testis-specific protein, tsHMG, which might account for the altered NER in testicular cells. To test this possibility, a human cervical carcinoma cell line (HeLa) was constructed which ectopically expressed tsHMG under the control of an inducible promoter. Microscopic examination of tsHMG expression and cisplatin-induced apoptosis on a cellular level revealed that the nuclear protein did indeed modulate the cytotoxic consequences of cisplatin treatment. Also, tsHMG enhanced transcription inhibition by cisplatin. These results reveal that an HMG-domain protein can affect cellular responses to cisplatin and may be relevant to the clinical observation that cancer cells in specific tissues are particularly sensitive to cisplatin. | lld:pubmed |
| pubmed-article:12175937 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12175937 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12175937 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12175937 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12175937 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12175937 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12175937 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12175937 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12175937 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12175937 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12175937 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12175937 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:12175937 | pubmed:issn | 0162-0134 | lld:pubmed |
| pubmed-article:12175937 | pubmed:author | pubmed-author:LippardStephe... | lld:pubmed |
| pubmed-article:12175937 | pubmed:author | pubmed-author:ZambleDeborah... | lld:pubmed |
| pubmed-article:12175937 | pubmed:author | pubmed-author:MikataYujiY | lld:pubmed |
| pubmed-article:12175937 | pubmed:author | pubmed-author:EngChristina... | lld:pubmed |
| pubmed-article:12175937 | pubmed:author | pubmed-author:SandmanKaren... | lld:pubmed |
| pubmed-article:12175937 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12175937 | pubmed:day | 30 | lld:pubmed |
| pubmed-article:12175937 | pubmed:volume | 91 | lld:pubmed |
| pubmed-article:12175937 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12175937 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12175937 | pubmed:pagination | 451-62 | lld:pubmed |
| pubmed-article:12175937 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:12175937 | pubmed:meshHeading | pubmed-meshheading:12175937... | lld:pubmed |
| pubmed-article:12175937 | pubmed:meshHeading | pubmed-meshheading:12175937... | lld:pubmed |
| pubmed-article:12175937 | pubmed:meshHeading | pubmed-meshheading:12175937... | lld:pubmed |
| pubmed-article:12175937 | pubmed:meshHeading | pubmed-meshheading:12175937... | lld:pubmed |
| pubmed-article:12175937 | pubmed:meshHeading | pubmed-meshheading:12175937... | lld:pubmed |
| pubmed-article:12175937 | pubmed:meshHeading | pubmed-meshheading:12175937... | lld:pubmed |
| pubmed-article:12175937 | pubmed:meshHeading | pubmed-meshheading:12175937... | lld:pubmed |
| pubmed-article:12175937 | pubmed:meshHeading | pubmed-meshheading:12175937... | lld:pubmed |
| pubmed-article:12175937 | pubmed:meshHeading | pubmed-meshheading:12175937... | lld:pubmed |
| pubmed-article:12175937 | pubmed:meshHeading | pubmed-meshheading:12175937... | lld:pubmed |
| pubmed-article:12175937 | pubmed:meshHeading | pubmed-meshheading:12175937... | lld:pubmed |
| pubmed-article:12175937 | pubmed:meshHeading | pubmed-meshheading:12175937... | lld:pubmed |
| pubmed-article:12175937 | pubmed:meshHeading | pubmed-meshheading:12175937... | lld:pubmed |
| pubmed-article:12175937 | pubmed:meshHeading | pubmed-meshheading:12175937... | lld:pubmed |
| pubmed-article:12175937 | pubmed:meshHeading | pubmed-meshheading:12175937... | lld:pubmed |
| pubmed-article:12175937 | pubmed:meshHeading | pubmed-meshheading:12175937... | lld:pubmed |
| pubmed-article:12175937 | pubmed:meshHeading | pubmed-meshheading:12175937... | lld:pubmed |
| pubmed-article:12175937 | pubmed:meshHeading | pubmed-meshheading:12175937... | lld:pubmed |
| pubmed-article:12175937 | pubmed:meshHeading | pubmed-meshheading:12175937... | lld:pubmed |
| pubmed-article:12175937 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12175937 | pubmed:articleTitle | Testis-specific HMG-domain protein alters the responses of cells to cisplatin. | lld:pubmed |
| pubmed-article:12175937 | pubmed:affiliation | Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139-4307, USA. | lld:pubmed |
| pubmed-article:12175937 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12175937 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12175937 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12175937 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12175937 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12175937 | lld:pubmed |
