| pubmed-article:12170771 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12170771 | lifeskim:mentions | umls-concept:C1704256 | lld:lifeskim |
| pubmed-article:12170771 | lifeskim:mentions | umls-concept:C0151692 | lld:lifeskim |
| pubmed-article:12170771 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:12170771 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:12170771 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:12170771 | lifeskim:mentions | umls-concept:C0762592 | lld:lifeskim |
| pubmed-article:12170771 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:12170771 | pubmed:dateCreated | 2002-8-12 | lld:pubmed |
| pubmed-article:12170771 | pubmed:abstractText | Angiogenesis, development of new blood vessels, is essential for wound healing and tumor growth. A potentially important side effect of anti-angiogenic therapy can be delayed wound healing. In this study we address this issue by using a novel in vivo method utilizing fibrin containing dual porous plexiglass chambers (Fibrin Z-Chambers; F-ZC) to investigate wound healing in rats administered with SU5416 (inhibitor of Flk-1 and Flt-1, at 20 mg/kg i.p.). SU5416 treated F-ZCs developed 45% less granulation tissue (p = 0.0076) and showed a 10% reduction in microvessel density (p = 0.0009) than controls treated with drug carrier alone. The granulation tissue showed distinctly decreased collagen deposition (p = 0.0006) in SU5416 treated animals that was associated with 90% reduction in active TGF-beta 1 level. We found that tissue transglutaminase (TG), a cross-linking enzyme involved in TGF-beta 1 activation and matrix stabilization, was inhibited by SU5416. These results suggest that SU5416 delays wound healing by reducing matrix synthesis and stabilization through inhibition of TGF-beta 1 activation. This study was made feasible via the development of a unique method to study anti-angiogenic compounds that provides highly reproducible and quantitative results. Further studies are needed to evaluate in vivo whether anti-angiogenic agents alter wound healing. | lld:pubmed |
| pubmed-article:12170771 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12170771 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12170771 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12170771 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12170771 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12170771 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12170771 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12170771 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12170771 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12170771 | pubmed:issn | 1538-4047 | lld:pubmed |
| pubmed-article:12170771 | pubmed:author | pubmed-author:WilsonWilliam... | lld:pubmed |
| pubmed-article:12170771 | pubmed:author | pubmed-author:GreenbergChar... | lld:pubmed |
| pubmed-article:12170771 | pubmed:author | pubmed-author:DewhirstMark... | lld:pubmed |
| pubmed-article:12170771 | pubmed:author | pubmed-author:AminKhalidK | lld:pubmed |
| pubmed-article:12170771 | pubmed:author | pubmed-author:HaroonZishan... | lld:pubmed |
| pubmed-article:12170771 | pubmed:author | pubmed-author:SaitoWilfredW | lld:pubmed |
| pubmed-article:12170771 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12170771 | pubmed:volume | 1 | lld:pubmed |
| pubmed-article:12170771 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12170771 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12170771 | pubmed:pagination | 121-6 | lld:pubmed |
| pubmed-article:12170771 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:12170771 | pubmed:meshHeading | pubmed-meshheading:12170771... | lld:pubmed |
| pubmed-article:12170771 | pubmed:articleTitle | SU5416 delays wound healing through inhibition of TGF-beta 1 activation. | lld:pubmed |
| pubmed-article:12170771 | pubmed:affiliation | Box 3455, Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA. zishan.haroon@sri.com | lld:pubmed |
| pubmed-article:12170771 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12170771 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12170771 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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