| pubmed-article:12168335 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12168335 | lifeskim:mentions | umls-concept:C0459385 | lld:lifeskim |
| pubmed-article:12168335 | lifeskim:mentions | umls-concept:C0228174 | lld:lifeskim |
| pubmed-article:12168335 | lifeskim:mentions | umls-concept:C0242706 | lld:lifeskim |
| pubmed-article:12168335 | lifeskim:mentions | umls-concept:C0221198 | lld:lifeskim |
| pubmed-article:12168335 | lifeskim:mentions | umls-concept:C1536627 | lld:lifeskim |
| pubmed-article:12168335 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:12168335 | lifeskim:mentions | umls-concept:C0205234 | lld:lifeskim |
| pubmed-article:12168335 | pubmed:dateCreated | 2002-8-9 | lld:pubmed |
| pubmed-article:12168335 | pubmed:abstractText | We evaluated the systemic and cerebral effects induced by an increase to 100% of the inspired oxygen fraction (FiO2) on 20 comatose patients with head injury (9 patients) and SAH (11 patients). Brain tissue oxygen tension (PtiO2) was measured through a Clark electrode inserted in penumbra-like areas. We performed 55 hyperoxia tests by increasing FiO2 from 35 +/- 8% to 100% in one second and calculating the PtiO2 index as: PtiO2 variation from baseline at 1 minute/arterial oxygen tension (PaO2) variation from baseline at 1 minute x 100. One hundred percent FiO2 caused an increase of both arterial (from 139 +/- 28 to 396 +/- 77 mmHg) and cerebral (from 22.6 +/- 14 to 65.4 +/- 60 mmHg) oxygenation after 1 minute. The range of the PtiO2 response was not uniform and two groups were identified. The change was small, 0.8 mmHg/min/100 mmHg PaO2 (+/- 0.7; range 0-2) when mean PtiO2 was 19.7 +/- 13.1 mmHg, while a stronger response, 8 mmHg/min/100 mmHg PaO2 (+/- 5; range 3-18) (p < 0.01) was found when mean PtiO2 was 31.7 +/- 14.3 mmHg. Since O2 diffusion should follow the gas diffusion law, the increase in diffusion distance due to a reduction of capillary density in focal lesions may explain this relationship. | lld:pubmed |
| pubmed-article:12168335 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12168335 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12168335 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12168335 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12168335 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12168335 | pubmed:issn | 0065-1419 | lld:pubmed |
| pubmed-article:12168335 | pubmed:author | pubmed-author:De MarchiMM | lld:pubmed |
| pubmed-article:12168335 | pubmed:author | pubmed-author:RossiSS | lld:pubmed |
| pubmed-article:12168335 | pubmed:author | pubmed-author:LonghiLL | lld:pubmed |
| pubmed-article:12168335 | pubmed:author | pubmed-author:StocchettiNN | lld:pubmed |
| pubmed-article:12168335 | pubmed:author | pubmed-author:ValerianiVV | lld:pubmed |
| pubmed-article:12168335 | pubmed:author | pubmed-author:EgidiMM | lld:pubmed |
| pubmed-article:12168335 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12168335 | pubmed:volume | 81 | lld:pubmed |
| pubmed-article:12168335 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12168335 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12168335 | pubmed:pagination | 315-7 | lld:pubmed |
| pubmed-article:12168335 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:12168335 | pubmed:meshHeading | pubmed-meshheading:12168335... | lld:pubmed |
| pubmed-article:12168335 | pubmed:meshHeading | pubmed-meshheading:12168335... | lld:pubmed |
| pubmed-article:12168335 | pubmed:meshHeading | pubmed-meshheading:12168335... | lld:pubmed |
| pubmed-article:12168335 | pubmed:meshHeading | pubmed-meshheading:12168335... | lld:pubmed |
| pubmed-article:12168335 | pubmed:meshHeading | pubmed-meshheading:12168335... | lld:pubmed |
| pubmed-article:12168335 | pubmed:meshHeading | pubmed-meshheading:12168335... | lld:pubmed |
| pubmed-article:12168335 | pubmed:meshHeading | pubmed-meshheading:12168335... | lld:pubmed |
| pubmed-article:12168335 | pubmed:meshHeading | pubmed-meshheading:12168335... | lld:pubmed |
| pubmed-article:12168335 | pubmed:meshHeading | pubmed-meshheading:12168335... | lld:pubmed |
| pubmed-article:12168335 | pubmed:meshHeading | pubmed-meshheading:12168335... | lld:pubmed |
| pubmed-article:12168335 | pubmed:meshHeading | pubmed-meshheading:12168335... | lld:pubmed |
| pubmed-article:12168335 | pubmed:meshHeading | pubmed-meshheading:12168335... | lld:pubmed |
| pubmed-article:12168335 | pubmed:meshHeading | pubmed-meshheading:12168335... | lld:pubmed |
| pubmed-article:12168335 | pubmed:meshHeading | pubmed-meshheading:12168335... | lld:pubmed |
| pubmed-article:12168335 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12168335 | pubmed:articleTitle | Effects of hyperoxia on brain tissue oxygen tension in cerebral focal lesions. | lld:pubmed |
| pubmed-article:12168335 | pubmed:affiliation | Department of Anesthesia and Intensive Care, Ospedale Maggiore Policlinico IRCCS, Milano, Italy. | lld:pubmed |
| pubmed-article:12168335 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12168335 | lld:pubmed |
