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pubmed-article:12168107pubmed:abstractTextRadiofrequency ablation (RFA) is an effective modality for the treatment of hepatocellular carcinoma (HCC), because it can induce large coagulated necrosis in a few sessions. We have recently reported that the combination therapy of percutaneous ethanol injection (PEI) with RFA (PEI-RFA) created enhancement of coagulated necrosis compared with RFA alone. In the present study, we adopted PEI-RFA for the treatment of HCCs located in the regions that are difficult to treat with RFA alone. Five patients with biopsy-proven HCC and liver cirrhosis underwent PEI-RFA therapy. In these patients, HCCs were located beside the gallbladder, inferior vena cava or portal vein or kidney, or immediately under the diaphragm. Prior to RFA, 99.5% ethanol was injected into the region of HCC located in the regions where RFA energy appears to be difficult to reach. In all cases, HCC was totally coagulated by PEI-RFA. Injecting ethanol prior to RFA therapy caused no major side effects. These results indicate that PEI-RFA may be effective for the treatment of HCCs located in the regions that are difficult to treat with RFA alone as well as large-sized HCCs.lld:pubmed
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pubmed-article:12168107pubmed:authorpubmed-author:MurotaMasayuk...lld:pubmed
pubmed-article:12168107pubmed:authorpubmed-author:KuriyamaShige...lld:pubmed
pubmed-article:12168107pubmed:authorpubmed-author:YoshidaShuhei...lld:pubmed
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pubmed-article:12168107pubmed:authorpubmed-author:KurokohchiKaz...lld:pubmed
pubmed-article:12168107pubmed:authorpubmed-author:MiyauchiYoshi...lld:pubmed
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pubmed-article:12168107pubmed:volume21lld:pubmed
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pubmed-article:12168107pubmed:pagination611-5lld:pubmed
pubmed-article:12168107pubmed:dateRevised2004-11-17lld:pubmed
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pubmed-article:12168107pubmed:year2002lld:pubmed
pubmed-article:12168107pubmed:articleTitleCombination therapy of percutaneous ethanol injection and radiofrequency ablation against hepatocellular carcinomas difficult to treat.lld:pubmed
pubmed-article:12168107pubmed:affiliationThird Department of Internal Medicine, Kagawa Medical University, 1750-1 Ikenobe, Miki-cho, Kagawa 761-0793, Japan.lld:pubmed
pubmed-article:12168107pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:12168107pubmed:publicationTypeClinical Triallld:pubmed
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