| pubmed-article:121675 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:121675 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:121675 | lifeskim:mentions | umls-concept:C1704387 | lld:lifeskim |
| pubmed-article:121675 | lifeskim:mentions | umls-concept:C1522642 | lld:lifeskim |
| pubmed-article:121675 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:121675 | lifeskim:mentions | umls-concept:C1947989 | lld:lifeskim |
| pubmed-article:121675 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:121675 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:121675 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:121675 | lifeskim:mentions | umls-concept:C1522492 | lld:lifeskim |
| pubmed-article:121675 | pubmed:issue | 5-6 | lld:pubmed |
| pubmed-article:121675 | pubmed:dateCreated | 1980-10-27 | lld:pubmed |
| pubmed-article:121675 | pubmed:abstractText | Human lymphocytes stimulated with PHA in liquid phase (step 1) and then seeded in a two-layer soft agar system (step 2) grew and developed into T cell colonies. Colony formation was enhanced when the agar culture was supplemented with culture fluid obtained from phytohemagglutin-treated lymphocytes (Ly-CF). Untreated lymphocytes plated directly in the soft agar system also developed into colonies if the culture medium contained Ly-CF. Mitogen-sensitized T lymphocytes produced a lymphocyte colony enhancing factor in the culture fluid which stimulated lymphocytes into colony formation. The best plating efficiency (1:250) was attained when blood mononuclear cells were seeded. When spleen cell culture fluid or a highly concentrated blood-adherent cell population was added to the soft agar, colony development was strongly inhibited. Monocytes-macrophages secrete a lymphocyte colony inhibiting factor in the culture medium. These lymphokines exert a competitive influence on T cells and thus control and regulate clonal proliferation. | lld:pubmed |
| pubmed-article:121675 | pubmed:language | eng | lld:pubmed |
| pubmed-article:121675 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:121675 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:121675 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:121675 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:121675 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:121675 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:121675 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:121675 | pubmed:issn | 0001-5792 | lld:pubmed |
| pubmed-article:121675 | pubmed:author | pubmed-author:RozenszajnL... | lld:pubmed |
| pubmed-article:121675 | pubmed:author | pubmed-author:GoldmanII | lld:pubmed |
| pubmed-article:121675 | pubmed:author | pubmed-author:ZeeviAA | lld:pubmed |
| pubmed-article:121675 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:121675 | pubmed:volume | 62 | lld:pubmed |
| pubmed-article:121675 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:121675 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:121675 | pubmed:pagination | 315-21 | lld:pubmed |
| pubmed-article:121675 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
| pubmed-article:121675 | pubmed:meshHeading | pubmed-meshheading:121675-H... | lld:pubmed |
| pubmed-article:121675 | pubmed:meshHeading | pubmed-meshheading:121675-A... | lld:pubmed |
| pubmed-article:121675 | pubmed:meshHeading | pubmed-meshheading:121675-L... | lld:pubmed |
| pubmed-article:121675 | pubmed:meshHeading | pubmed-meshheading:121675-C... | lld:pubmed |
| pubmed-article:121675 | pubmed:meshHeading | pubmed-meshheading:121675-C... | lld:pubmed |
| pubmed-article:121675 | pubmed:meshHeading | pubmed-meshheading:121675-L... | lld:pubmed |
| pubmed-article:121675 | pubmed:meshHeading | pubmed-meshheading:121675-P... | lld:pubmed |
| pubmed-article:121675 | pubmed:meshHeading | pubmed-meshheading:121675-C... | lld:pubmed |
| pubmed-article:121675 | pubmed:meshHeading | pubmed-meshheading:121675-L... | lld:pubmed |
| pubmed-article:121675 | pubmed:meshHeading | pubmed-meshheading:121675-T... | lld:pubmed |
| pubmed-article:121675 | pubmed:meshHeading | pubmed-meshheading:121675-C... | lld:pubmed |
| pubmed-article:121675 | pubmed:year | 1979 | lld:pubmed |
| pubmed-article:121675 | pubmed:articleTitle | Colony growth of T lymphocytes in vitro. Control and regulation of clonal formation. | lld:pubmed |
| pubmed-article:121675 | pubmed:publicationType | Journal Article | lld:pubmed |
