| pubmed-article:12164917 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12164917 | lifeskim:mentions | umls-concept:C1123023 | lld:lifeskim |
| pubmed-article:12164917 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:12164917 | lifeskim:mentions | umls-concept:C0876956 | lld:lifeskim |
| pubmed-article:12164917 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:12164917 | pubmed:dateCreated | 2002-8-7 | lld:pubmed |
| pubmed-article:12164917 | pubmed:abstractText | To study the phenotypic changes in human skin associated with repeated sun exposure at the transcription level, we have undertaken a comparative serial analysis of gene expression of sun-damaged preauricular skin and sun-protected postauricular skin as well as sun-protected epidermis. Serial analyses of gene expression libraries, containing multiple mRNA-derived tag recombinants, were made to poly(A+)RNA isolated from human postauricular skin and preauricular skin, as well as epidermal nick biopsy samples. 5330 mRNA-derived cDNA tags from the postauricular serial analysis of gene expression library were sequenced and these tag sequences were compared to cDNA sequences identified from 5105 tags analyzed from a preauricular serial analysis of gene expression library. Of the total of 4742 different tags represented in both libraries we found 34 tags with at least a 4-fold difference of tag abundance between the libraries. Among the mRNAs with altered steady-state(1) levels in sun-damaged skin, we detected those encoding keratin 1, macrophage inhibitory factor, and calmodulin-like skin protein. In addition, a comparison of cDNA sequences identified in the serial analysis of gene expression libraries obtained from the epidermal biopsy samples (5257 cDNA tags) and from both full-thickness skin samples indicated that many genes with altered steady-state transcript levels upon sun exposure were expressed in epidermal keratinocytes. These results suggest a major role for the epidermis in the pathomechanism of largely dermal changes in chronically sun-exposed skin. | lld:pubmed |
| pubmed-article:12164917 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12164917 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12164917 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12164917 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12164917 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12164917 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12164917 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:12164917 | pubmed:issn | 0022-202X | lld:pubmed |
| pubmed-article:12164917 | pubmed:author | pubmed-author:CsiszarKatali... | lld:pubmed |
| pubmed-article:12164917 | pubmed:author | pubmed-author:BoydCharles... | lld:pubmed |
| pubmed-article:12164917 | pubmed:author | pubmed-author:ScottIanI | lld:pubmed |
| pubmed-article:12164917 | pubmed:author | pubmed-author:UrschitzJohan... | lld:pubmed |
| pubmed-article:12164917 | pubmed:author | pubmed-author:IobstSusanneS | lld:pubmed |
| pubmed-article:12164917 | pubmed:author | pubmed-author:UrbanZsoltZ | lld:pubmed |
| pubmed-article:12164917 | pubmed:author | pubmed-author:GrandaChiaC | lld:pubmed |
| pubmed-article:12164917 | pubmed:author | pubmed-author:SouzaKathleen... | lld:pubmed |
| pubmed-article:12164917 | pubmed:author | pubmed-author:LuppClaudiaC | lld:pubmed |
| pubmed-article:12164917 | pubmed:author | pubmed-author:SchillingKurt... | lld:pubmed |
| pubmed-article:12164917 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12164917 | pubmed:volume | 119 | lld:pubmed |
| pubmed-article:12164917 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12164917 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12164917 | pubmed:pagination | 3-13 | lld:pubmed |
| pubmed-article:12164917 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:12164917 | pubmed:meshHeading | pubmed-meshheading:12164917... | lld:pubmed |
| pubmed-article:12164917 | pubmed:meshHeading | pubmed-meshheading:12164917... | lld:pubmed |
| pubmed-article:12164917 | pubmed:meshHeading | pubmed-meshheading:12164917... | lld:pubmed |
| pubmed-article:12164917 | pubmed:meshHeading | pubmed-meshheading:12164917... | lld:pubmed |
| pubmed-article:12164917 | pubmed:meshHeading | pubmed-meshheading:12164917... | lld:pubmed |
| pubmed-article:12164917 | pubmed:meshHeading | pubmed-meshheading:12164917... | lld:pubmed |
| pubmed-article:12164917 | pubmed:meshHeading | pubmed-meshheading:12164917... | lld:pubmed |
| pubmed-article:12164917 | pubmed:meshHeading | pubmed-meshheading:12164917... | lld:pubmed |
| pubmed-article:12164917 | pubmed:meshHeading | pubmed-meshheading:12164917... | lld:pubmed |
| pubmed-article:12164917 | pubmed:meshHeading | pubmed-meshheading:12164917... | lld:pubmed |
| pubmed-article:12164917 | pubmed:meshHeading | pubmed-meshheading:12164917... | lld:pubmed |
| pubmed-article:12164917 | pubmed:meshHeading | pubmed-meshheading:12164917... | lld:pubmed |
| pubmed-article:12164917 | pubmed:meshHeading | pubmed-meshheading:12164917... | lld:pubmed |
| pubmed-article:12164917 | pubmed:meshHeading | pubmed-meshheading:12164917... | lld:pubmed |
| pubmed-article:12164917 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12164917 | pubmed:articleTitle | A serial analysis of gene expression in sun-damaged human skin. | lld:pubmed |
| pubmed-article:12164917 | pubmed:affiliation | The Pacific Biomedical Research Center, University of Hawaii, 1993 East-West Road, Honolulu, HI 96822, U.S.A. | lld:pubmed |
| pubmed-article:12164917 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12164917 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12164917 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
