| pubmed-article:12163589 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12163589 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:12163589 | lifeskim:mentions | umls-concept:C0021311 | lld:lifeskim |
| pubmed-article:12163589 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
| pubmed-article:12163589 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
| pubmed-article:12163589 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
| pubmed-article:12163589 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:12163589 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:12163589 | lifeskim:mentions | umls-concept:C0205178 | lld:lifeskim |
| pubmed-article:12163589 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
| pubmed-article:12163589 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
| pubmed-article:12163589 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:12163589 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:12163589 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:12163589 | lifeskim:mentions | umls-concept:C0205369 | lld:lifeskim |
| pubmed-article:12163589 | lifeskim:mentions | umls-concept:C0449774 | lld:lifeskim |
| pubmed-article:12163589 | lifeskim:mentions | umls-concept:C0332290 | lld:lifeskim |
| pubmed-article:12163589 | pubmed:issue | 17 | lld:pubmed |
| pubmed-article:12163589 | pubmed:dateCreated | 2002-8-6 | lld:pubmed |
| pubmed-article:12163589 | pubmed:abstractText | Human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T-cell responses generated during acute infection play a critical role in the initial control of viremia. However, little is known about the viral T-cell epitopes targeted during acute infection or about their hierarchy in appearance and relative immunodominance over time. In this study, HIV-1-specific CD8+ T-cell responses in 18 acutely infected individuals expressing HLA-A3 and/or -B7 were characterized. Detailed analysis of CD8 responses in one such person who underwent treatment of acute infection followed by reexposure to HIV-1 through supervised treatment interruptions (STI) revealed recognition of only two cytotoxic T-lymphocyte (CTL) epitopes during symptomatic acute infection. HIV-1-specific CD8+ T-cell responses broadened significantly during subsequent exposure to the virus, ultimately targeting 27 distinct CTL epitopes, including 15 different CTL epitopes restricted by a single HLA class I allele (HLA-A3). The same few peptides were consistently targeted in an additional 17 persons expressing HLA-A3 and/or -B7 during acute infection. These studies demonstrate a consistent pattern in the development of epitope-specific responses restricted by a single HLA allele during acute HIV-1 infection, as well as persistence of the initial pattern of immunodominance during subsequent STI. In addition, they demonstrate that HIV-1-specific CD8+ T-cell responses can ultimately target a previously unexpected and unprecedented number of epitopes in a single infected individual, even though these are not detectable during the initial exposure to virus. These studies have important implications for vaccine design and evaluation. | lld:pubmed |
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| pubmed-article:12163589 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12163589 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12163589 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12163589 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12163589 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12163589 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12163589 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12163589 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:12163589 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:12163589 | pubmed:author | pubmed-author:WalkerBruce... | lld:pubmed |
| pubmed-article:12163589 | pubmed:author | pubmed-author:YuXu GXG | lld:pubmed |
| pubmed-article:12163589 | pubmed:author | pubmed-author:AddoMarylyn... | lld:pubmed |
| pubmed-article:12163589 | pubmed:author | pubmed-author:StrickDaryldD | lld:pubmed |
| pubmed-article:12163589 | pubmed:author | pubmed-author:GoulderPhilip... | lld:pubmed |
| pubmed-article:12163589 | pubmed:author | pubmed-author:RosenbergEric... | lld:pubmed |
| pubmed-article:12163589 | pubmed:author | pubmed-author:AltfeldMarcus... | lld:pubmed |
| pubmed-article:12163589 | pubmed:author | pubmed-author:RodriguezWill... | lld:pubmed |
| pubmed-article:12163589 | pubmed:author | pubmed-author:LeePaul KPK | lld:pubmed |
| pubmed-article:12163589 | pubmed:author | pubmed-author:FitzpatrickCe... | lld:pubmed |
| pubmed-article:12163589 | pubmed:author | pubmed-author:JohnstonMary... | lld:pubmed |
| pubmed-article:12163589 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12163589 | pubmed:volume | 76 | lld:pubmed |
| pubmed-article:12163589 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12163589 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12163589 | pubmed:pagination | 8690-701 | lld:pubmed |
| pubmed-article:12163589 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
