| pubmed-article:12161550 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12161550 | lifeskim:mentions | umls-concept:C0032105 | lld:lifeskim |
| pubmed-article:12161550 | lifeskim:mentions | umls-concept:C0086045 | lld:lifeskim |
| pubmed-article:12161550 | lifeskim:mentions | umls-concept:C0021641 | lld:lifeskim |
| pubmed-article:12161550 | lifeskim:mentions | umls-concept:C0911014 | lld:lifeskim |
| pubmed-article:12161550 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:12161550 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:12161550 | pubmed:dateCreated | 2002-8-5 | lld:pubmed |
| pubmed-article:12161550 | pubmed:abstractText | Ghrelin is a novel gastric peptide which stimulates growth hormone and has orexigenic and adipogenic properties. Plasma ghrelin is influenced by nutritional status and is thought to play a role in regulating food intake and body weight. We examined the effect of infusing insulin (40 mU/m(2)/min) for 2 hours while maintaining euglycemia on plasma ghrelin in 8 subjects (5 M, 3 F) aged 46 +/- 4 yrs (mean +/- SEM). Plasma insulin increased from 78 +/- 9 to 564 +/- 23 pmol/L during and returned rapidly to basal values after stopping the insulin infusion. Plasma ghrelin decreased from 85 +/- 28 to 61 +/- 18 pmol/L (p < 0.01) by 90 minutes of and continued to be suppressed for 15 minutes after the insulin infusion was discontinued. Subsequently, plasma ghrelin rose rapidly to near-basal values (81 +/- 23 pmol/L) within 60 minutes. The reciprocal relation between insulin and ghrelin was observed consistently in all subjects with the maximum insulin-induced suppression of ghrelin ranging from 19 to 64% (mean 32 +/- 5) and occurring 90-135 minutes after starting the insulin infusion (median 120). These findings indicate that insulin is a physiological and dynamic modulator of plasma ghrelin and that insulinemia possibly mediates the effect of nutritional status on its concentration. | lld:pubmed |
| pubmed-article:12161550 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12161550 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12161550 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12161550 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:12161550 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12161550 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12161550 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12161550 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:12161550 | pubmed:issn | 0021-972X | lld:pubmed |
| pubmed-article:12161550 | pubmed:author | pubmed-author:SaadMohammed... | lld:pubmed |
| pubmed-article:12161550 | pubmed:author | pubmed-author:HwuChii-MinCM | lld:pubmed |
| pubmed-article:12161550 | pubmed:author | pubmed-author:BernabaBasemB | lld:pubmed |
| pubmed-article:12161550 | pubmed:author | pubmed-author:JinagoudaSuja... | lld:pubmed |
| pubmed-article:12161550 | pubmed:author | pubmed-author:FahmiSalwaS | lld:pubmed |
| pubmed-article:12161550 | pubmed:author | pubmed-author:KogosovEllaE | lld:pubmed |
| pubmed-article:12161550 | pubmed:author | pubmed-author:BoyadjianRima... | lld:pubmed |
| pubmed-article:12161550 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12161550 | pubmed:volume | 87 | lld:pubmed |
| pubmed-article:12161550 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12161550 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12161550 | pubmed:pagination | 3997-4000 | lld:pubmed |
| pubmed-article:12161550 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:12161550 | pubmed:meshHeading | pubmed-meshheading:12161550... | lld:pubmed |
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| pubmed-article:12161550 | pubmed:meshHeading | pubmed-meshheading:12161550... | lld:pubmed |
| pubmed-article:12161550 | pubmed:meshHeading | pubmed-meshheading:12161550... | lld:pubmed |
| pubmed-article:12161550 | pubmed:meshHeading | pubmed-meshheading:12161550... | lld:pubmed |
| pubmed-article:12161550 | pubmed:meshHeading | pubmed-meshheading:12161550... | lld:pubmed |
| pubmed-article:12161550 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12161550 | pubmed:articleTitle | Insulin regulates plasma ghrelin concentration. | lld:pubmed |
| pubmed-article:12161550 | pubmed:affiliation | Division of Clinical Epidemiology and Preventive Medicine, UCLA School of Medicine, Los Angeles, California 90024, USA. msaad@mednet.ucla.edu | lld:pubmed |
| pubmed-article:12161550 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12161550 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:12161550 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12161550 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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