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pubmed-article:12161162pubmed:abstractTextA series of N-benzoyl-4-[(2,6-dichlorobenzoyl)amino]-L-phenylalanine derivatives was prepared in order to optimize the substitution on the N-benzoyl moiety for VCAM/VLA-4 antagonist activity. Disubstitution in the 2- and 6-positions is favored and a range of small alkyl and halogen are tolerated. A model of the bioactive conformation of these compounds is proposed.lld:pubmed
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pubmed-article:12161162pubmed:dateRevised2004-11-17lld:pubmed
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pubmed-article:12161162pubmed:articleTitleN-Aroyl-L-phenylalanine derivatives as VCAM/VLA-4 antagonists.lld:pubmed
pubmed-article:12161162pubmed:affiliationRoche Research Center, Hoffmann-La Roche Inc., Nutley, NJ 07110, USA. achyutharao.sidduri@roche.comlld:pubmed
pubmed-article:12161162pubmed:publicationTypeJournal Articlelld:pubmed
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