| pubmed-article:12154357 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12154357 | lifeskim:mentions | umls-concept:C0205160 | lld:lifeskim |
| pubmed-article:12154357 | lifeskim:mentions | umls-concept:C0015744 | lld:lifeskim |
| pubmed-article:12154357 | lifeskim:mentions | umls-concept:C2911691 | lld:lifeskim |
| pubmed-article:12154357 | lifeskim:mentions | umls-concept:C1819479 | lld:lifeskim |
| pubmed-article:12154357 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:12154357 | pubmed:dateCreated | 2002-9-2 | lld:pubmed |
| pubmed-article:12154357 | pubmed:abstractText | Although interleukin 12 (IL-12) production by dendritic cells (DCs) confers protection against harmful invasions by regulating both innate and adaptive immunity, its dysregulation may have detrimental effects on the host. We show here that phosphoinositide 3-kinase (PI3K) negatively regulates IL-12 synthesis by DCs. We found that numerous stimuli that induced IL-12 production concomitantly elicited PI3K activation in DCs, but both PI3K(-/-) and PI3K inhibitor#150;treated DCs showed increased IL-12 production. Accordingly, an enhanced T helper type 1 (T(H)1) response was observed upon Leishmania major infection in PI3K(-/-) mice. Our findings indicate that a negative feedback mechanism exists that regulates IL-12 production during DC activation and may help prevent the excessive T(H)1 polarization that causes undesirable immune responses. | lld:pubmed |
| pubmed-article:12154357 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12154357 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12154357 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12154357 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12154357 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12154357 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12154357 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12154357 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12154357 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12154357 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12154357 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12154357 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:12154357 | pubmed:issn | 1529-2908 | lld:pubmed |
| pubmed-article:12154357 | pubmed:author | pubmed-author:AsanoTomoichi... | lld:pubmed |
| pubmed-article:12154357 | pubmed:author | pubmed-author:KadowakiTakas... | lld:pubmed |
| pubmed-article:12154357 | pubmed:author | pubmed-author:TerauchiYasuo... | lld:pubmed |
| pubmed-article:12154357 | pubmed:author | pubmed-author:TakeuchiTsuto... | lld:pubmed |
| pubmed-article:12154357 | pubmed:author | pubmed-author:OtaTakayukiT | lld:pubmed |
| pubmed-article:12154357 | pubmed:author | pubmed-author:KoyasuShigeoS | lld:pubmed |
| pubmed-article:12154357 | pubmed:author | pubmed-author:FukaoTaroT | lld:pubmed |
| pubmed-article:12154357 | pubmed:author | pubmed-author:TanabeMasanob... | lld:pubmed |
| pubmed-article:12154357 | pubmed:author | pubmed-author:MatsudaSatosh... | lld:pubmed |
| pubmed-article:12154357 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12154357 | pubmed:volume | 3 | lld:pubmed |
| pubmed-article:12154357 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12154357 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12154357 | pubmed:pagination | 875-81 | lld:pubmed |
| pubmed-article:12154357 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:12154357 | pubmed:meshHeading | pubmed-meshheading:12154357... | lld:pubmed |
| pubmed-article:12154357 | pubmed:meshHeading | pubmed-meshheading:12154357... | lld:pubmed |
| pubmed-article:12154357 | pubmed:meshHeading | pubmed-meshheading:12154357... | lld:pubmed |
| pubmed-article:12154357 | pubmed:meshHeading | pubmed-meshheading:12154357... | lld:pubmed |
| pubmed-article:12154357 | pubmed:meshHeading | pubmed-meshheading:12154357... | lld:pubmed |
| pubmed-article:12154357 | pubmed:meshHeading | pubmed-meshheading:12154357... | lld:pubmed |
| pubmed-article:12154357 | pubmed:meshHeading | pubmed-meshheading:12154357... | lld:pubmed |
| pubmed-article:12154357 | pubmed:meshHeading | pubmed-meshheading:12154357... | lld:pubmed |
| pubmed-article:12154357 | pubmed:meshHeading | pubmed-meshheading:12154357... | lld:pubmed |
| pubmed-article:12154357 | pubmed:meshHeading | pubmed-meshheading:12154357... | lld:pubmed |
| pubmed-article:12154357 | pubmed:meshHeading | pubmed-meshheading:12154357... | lld:pubmed |
| pubmed-article:12154357 | pubmed:meshHeading | pubmed-meshheading:12154357... | lld:pubmed |
| pubmed-article:12154357 | pubmed:meshHeading | pubmed-meshheading:12154357... | lld:pubmed |
| pubmed-article:12154357 | pubmed:meshHeading | pubmed-meshheading:12154357... | lld:pubmed |
| pubmed-article:12154357 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12154357 | pubmed:articleTitle | PI3K-mediated negative feedback regulation of IL-12 production in DCs. | lld:pubmed |
| pubmed-article:12154357 | pubmed:affiliation | Department of Microbiology and Immunology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. | lld:pubmed |
| pubmed-article:12154357 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12154357 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12154357 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12154357 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12154357 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12154357 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12154357 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12154357 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12154357 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12154357 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12154357 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12154357 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12154357 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12154357 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12154357 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12154357 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12154357 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12154357 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12154357 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12154357 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12154357 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12154357 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12154357 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12154357 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12154357 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12154357 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12154357 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12154357 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12154357 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12154357 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12154357 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12154357 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12154357 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12154357 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12154357 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12154357 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12154357 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12154357 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12154357 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12154357 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12154357 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12154357 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12154357 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12154357 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12154357 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12154357 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12154357 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12154357 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12154357 | lld:pubmed |
