| pubmed-article:12151598 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12151598 | lifeskim:mentions | umls-concept:C0383327 | lld:lifeskim |
| pubmed-article:12151598 | lifeskim:mentions | umls-concept:C1335877 | lld:lifeskim |
| pubmed-article:12151598 | lifeskim:mentions | umls-concept:C0020846 | lld:lifeskim |
| pubmed-article:12151598 | lifeskim:mentions | umls-concept:C0037284 | lld:lifeskim |
| pubmed-article:12151598 | lifeskim:mentions | umls-concept:C0333348 | lld:lifeskim |
| pubmed-article:12151598 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:12151598 | lifeskim:mentions | umls-concept:C0205369 | lld:lifeskim |
| pubmed-article:12151598 | lifeskim:mentions | umls-concept:C0205359 | lld:lifeskim |
| pubmed-article:12151598 | lifeskim:mentions | umls-concept:C1880177 | lld:lifeskim |
| pubmed-article:12151598 | lifeskim:mentions | umls-concept:C0348080 | lld:lifeskim |
| pubmed-article:12151598 | pubmed:issue | 17 | lld:pubmed |
| pubmed-article:12151598 | pubmed:dateCreated | 2002-8-21 | lld:pubmed |
| pubmed-article:12151598 | pubmed:abstractText | Atopic dermatitis (AD) is a pruritic inflammatory skin disease. Because IL-18 directly stimulates T cells and mast cells to release AD-associated molecules, Th2 cytokines, and histamine, we investigated the capacity of IL-18 to induce AD-like inflammatory skin disease by analyzing KIL-18Tg and KCASP1Tg, which skin-specifically overexpress IL-18 and caspase-1, respectively. They spontaneously developed relapsing dermatitis with mastocytosis and Th2 cytokine accumulation accompanied by systemic elevation of IgE and histamine. Stat6-deficient KCASP1Tg displayed undetectable levels of IgE but manifested the same degree of cutaneous changes, whereas IL-18-deficient KCASP1Tg evaded the dermatitis, suggesting that IL-18 causes the skin changes in the absence of IgE/stat6. KIL-18Tg and IL-1-deficient KCASP1Tg took longer to display the lesion than KCASP1Tg. Thus, AD-like inflammation is initiated by overrelease of IL-18 and accelerated by IL-1. Our present study might provide insight into understanding the pathogenesis of and establishing therapeutics for chronic inflammatory skin diseases including AD. | lld:pubmed |
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| pubmed-article:12151598 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12151598 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12151598 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12151598 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12151598 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:12151598 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:12151598 | pubmed:author | pubmed-author:TakedaKiyoshi... | lld:pubmed |
| pubmed-article:12151598 | pubmed:author | pubmed-author:AkiraShizuoS | lld:pubmed |
| pubmed-article:12151598 | pubmed:author | pubmed-author:SuzukiNoboruN | lld:pubmed |
| pubmed-article:12151598 | pubmed:author | pubmed-author:TsutsuiHiroko... | lld:pubmed |
| pubmed-article:12151598 | pubmed:author | pubmed-author:NakanishiKenj... | lld:pubmed |
| pubmed-article:12151598 | pubmed:author | pubmed-author:MizutaniHitos... | lld:pubmed |
| pubmed-article:12151598 | pubmed:author | pubmed-author:TanakaMinoruM | lld:pubmed |
| pubmed-article:12151598 | pubmed:author | pubmed-author:KonishiHirosh... | lld:pubmed |
| pubmed-article:12151598 | pubmed:author | pubmed-author:MurakamiTakaa... | lld:pubmed |
| pubmed-article:12151598 | pubmed:author | pubmed-author:Yumikura-Futa... | lld:pubmed |
| pubmed-article:12151598 | pubmed:author | pubmed-author:YamanakaKei-I... | lld:pubmed |
| pubmed-article:12151598 | pubmed:author | pubmed-author:IwakuraYohich... | lld:pubmed |
| pubmed-article:12151598 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12151598 | pubmed:day | 20 | lld:pubmed |
| pubmed-article:12151598 | pubmed:volume | 99 | lld:pubmed |
| pubmed-article:12151598 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12151598 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12151598 | pubmed:pagination | 11340-5 | lld:pubmed |
| pubmed-article:12151598 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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