pubmed-article:12142537 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:12142537 | lifeskim:mentions | umls-concept:C0598312 | lld:lifeskim |
pubmed-article:12142537 | lifeskim:mentions | umls-concept:C1155874 | lld:lifeskim |
pubmed-article:12142537 | lifeskim:mentions | umls-concept:C0243067 | lld:lifeskim |
pubmed-article:12142537 | lifeskim:mentions | umls-concept:C0546910 | lld:lifeskim |
pubmed-article:12142537 | pubmed:issue | 5581 | lld:pubmed |
pubmed-article:12142537 | pubmed:dateCreated | 2002-7-26 | lld:pubmed |
pubmed-article:12142537 | pubmed:abstractText | Checkpoint-mediated control of replicating chromosomes is essential for preventing cancer. In yeast, Rad53 kinase protects stalled replication forks from pathological rearrangements. To characterize the mechanisms controlling fork integrity, we analyzed replication intermediates formed in response to replication blocks using electron microscopy. At the forks, wild-type cells accumulate short single-stranded regions, which likely causes checkpoint activation, whereas rad53 mutants exhibit extensive single-stranded gaps and hemi-replicated intermediates, consistent with a lagging-strand synthesis defect. Further, rad53 cells accumulate Holliday junctions through fork reversal. We speculate that, in checkpoint mutants, abnormal replication intermediates begin to form because of uncoordinated replication and are further processed by unscheduled recombination pathways, causing genome instability. | lld:pubmed |
pubmed-article:12142537 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12142537 | pubmed:language | eng | lld:pubmed |
pubmed-article:12142537 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12142537 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:12142537 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12142537 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12142537 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12142537 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12142537 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12142537 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12142537 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12142537 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12142537 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12142537 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12142537 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:12142537 | pubmed:month | Jul | lld:pubmed |
pubmed-article:12142537 | pubmed:issn | 1095-9203 | lld:pubmed |
pubmed-article:12142537 | pubmed:author | pubmed-author:SogoJosé MJM | lld:pubmed |
pubmed-article:12142537 | pubmed:author | pubmed-author:LopesMassimoM | lld:pubmed |
pubmed-article:12142537 | pubmed:author | pubmed-author:FoianiMarcoM | lld:pubmed |
pubmed-article:12142537 | pubmed:issnType | Electronic | lld:pubmed |
pubmed-article:12142537 | pubmed:day | 26 | lld:pubmed |
pubmed-article:12142537 | pubmed:volume | 297 | lld:pubmed |
pubmed-article:12142537 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:12142537 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:12142537 | pubmed:pagination | 599-602 | lld:pubmed |
pubmed-article:12142537 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
pubmed-article:12142537 | pubmed:meshHeading | pubmed-meshheading:12142537... | lld:pubmed |
pubmed-article:12142537 | pubmed:meshHeading | pubmed-meshheading:12142537... | lld:pubmed |
pubmed-article:12142537 | pubmed:meshHeading | pubmed-meshheading:12142537... | lld:pubmed |
pubmed-article:12142537 | pubmed:meshHeading | pubmed-meshheading:12142537... | lld:pubmed |
pubmed-article:12142537 | pubmed:meshHeading | pubmed-meshheading:12142537... | lld:pubmed |
pubmed-article:12142537 | pubmed:meshHeading | pubmed-meshheading:12142537... | lld:pubmed |
pubmed-article:12142537 | pubmed:meshHeading | pubmed-meshheading:12142537... | lld:pubmed |
pubmed-article:12142537 | pubmed:meshHeading | pubmed-meshheading:12142537... | lld:pubmed |
pubmed-article:12142537 | pubmed:meshHeading | pubmed-meshheading:12142537... | lld:pubmed |
pubmed-article:12142537 | pubmed:meshHeading | pubmed-meshheading:12142537... | lld:pubmed |
pubmed-article:12142537 | pubmed:meshHeading | pubmed-meshheading:12142537... | lld:pubmed |
pubmed-article:12142537 | pubmed:meshHeading | pubmed-meshheading:12142537... | lld:pubmed |
pubmed-article:12142537 | pubmed:meshHeading | pubmed-meshheading:12142537... | lld:pubmed |
pubmed-article:12142537 | pubmed:meshHeading | pubmed-meshheading:12142537... | lld:pubmed |
pubmed-article:12142537 | pubmed:meshHeading | pubmed-meshheading:12142537... | lld:pubmed |
pubmed-article:12142537 | pubmed:meshHeading | pubmed-meshheading:12142537... | lld:pubmed |
pubmed-article:12142537 | pubmed:year | 2002 | lld:pubmed |
pubmed-article:12142537 | pubmed:articleTitle | Fork reversal and ssDNA accumulation at stalled replication forks owing to checkpoint defects. | lld:pubmed |
pubmed-article:12142537 | pubmed:affiliation | Institute of Cell Biology, ETH Hönggerberg, CH-8093 Zürich, Switzerland. | lld:pubmed |
pubmed-article:12142537 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:12142537 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12142537 | lld:pubmed |