| pubmed-article:12142409 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12142409 | lifeskim:mentions | umls-concept:C0038410 | lld:lifeskim |
| pubmed-article:12142409 | lifeskim:mentions | umls-concept:C0012854 | lld:lifeskim |
| pubmed-article:12142409 | lifeskim:mentions | umls-concept:C0020281 | lld:lifeskim |
| pubmed-article:12142409 | lifeskim:mentions | umls-concept:C1444783 | lld:lifeskim |
| pubmed-article:12142409 | lifeskim:mentions | umls-concept:C0314603 | lld:lifeskim |
| pubmed-article:12142409 | lifeskim:mentions | umls-concept:C1705914 | lld:lifeskim |
| pubmed-article:12142409 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:12142409 | lifeskim:mentions | umls-concept:C1880177 | lld:lifeskim |
| pubmed-article:12142409 | lifeskim:mentions | umls-concept:C0205227 | lld:lifeskim |
| pubmed-article:12142409 | lifeskim:mentions | umls-concept:C0075804 | lld:lifeskim |
| pubmed-article:12142409 | pubmed:issue | 16 | lld:pubmed |
| pubmed-article:12142409 | pubmed:dateCreated | 2002-7-26 | lld:pubmed |
| pubmed-article:12142409 | pubmed:abstractText | Loss-of-function mutations in the following seven pneumococcal genes were detected and analyzed: pspA, spxB, xba, licD2, lytA, nanA, and atpC. Factors associated with these mutations included (i) frameshifts caused by reversible gain and loss of single bases within homopolymeric repeats as short as 6 bases, (ii) deletions caused by recombinational events between nontandem direct repeats as short as 8 bases, and (iii) substitutions of guanine residues caused at an increased frequency by the high levels of hydrogen peroxide (>2 mM) typically generated by this species under aerobic growth conditions. The latter accounted for a frequency as high as 2.8 x 10(-6) for spontaneous mutation to resistance to optochin and was 10- to 200-fold lower in the absence of detectable levels of H2O2. Some of these mutations appear to have been selected for in vivo during pneumococcal infection, perhaps as a consequence of immune pressure or oxidative stress. | lld:pubmed |
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| pubmed-article:12142409 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12142409 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12142409 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12142409 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12142409 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:12142409 | pubmed:issn | 0021-9193 | lld:pubmed |
| pubmed-article:12142409 | pubmed:author | pubmed-author:WeiserJeffrey... | lld:pubmed |
| pubmed-article:12142409 | pubmed:author | pubmed-author:PericoneChris... | lld:pubmed |
| pubmed-article:12142409 | pubmed:author | pubmed-author:BaeDeborahD | lld:pubmed |
| pubmed-article:12142409 | pubmed:author | pubmed-author:ShchepetovMik... | lld:pubmed |
| pubmed-article:12142409 | pubmed:author | pubmed-author:McCoolTeraT | lld:pubmed |
| pubmed-article:12142409 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12142409 | pubmed:volume | 184 | lld:pubmed |
| pubmed-article:12142409 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12142409 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12142409 | pubmed:pagination | 4392-9 | lld:pubmed |
| pubmed-article:12142409 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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