Linked Life Data

12139292

Source:http://linkedlifedata.com/resource/pubmed/id/12139292

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pubmed-article:12139292pubmed:abstractTextNkx2.5 is a conserved homeodomain (HD) containing transcription factor essential for early cardiac development. We generated a DNA nonbinding missense mutation, I183P in the HD, similar to the missense HD mutation found in patients. Transgenic mice expressing this mutation under beta-MHC promoter [beta-MHC(I183P)] showed a postnatal lethal phenotype with heart failure. In contrast, mice expressing the mutation under alpha-MHC promoter [alpha-MHC(I183P)] survive, with later onset heart failure. The aim of this study was to investigate the interrelationship between lethal cardiac failure and the electrophysiologic (EP) phenotypes using cardiac-specific promoters with mutant gene expression at different stages of development and maturation.lld:pubmed
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pubmed-article:12139292pubmed:dateRevised2008-11-21lld:pubmed
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pubmed-article:12139292pubmed:articleTitleDevelopmentally modulated cardiac conduction failure in transgenic mice with fetal or postnatal overexpression of DNA nonbinding mutant Nkx2.5.lld:pubmed
pubmed-article:12139292pubmed:affiliationDepartment of Cardiology, Children's Hospital, Boston, Massachusetts 02115, USA.lld:pubmed
pubmed-article:12139292pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:12139292pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
pubmed-article:12139292pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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