pubmed-article:12138091 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:12138091 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
pubmed-article:12138091 | lifeskim:mentions | umls-concept:C0023820 | lld:lifeskim |
pubmed-article:12138091 | lifeskim:mentions | umls-concept:C0074129 | lld:lifeskim |
pubmed-article:12138091 | lifeskim:mentions | umls-concept:C0023779 | lld:lifeskim |
pubmed-article:12138091 | lifeskim:mentions | umls-concept:C0003595 | lld:lifeskim |
pubmed-article:12138091 | lifeskim:mentions | umls-concept:C0008387 | lld:lifeskim |
pubmed-article:12138091 | lifeskim:mentions | umls-concept:C1413218 | lld:lifeskim |
pubmed-article:12138091 | lifeskim:mentions | umls-concept:C1145667 | lld:lifeskim |
pubmed-article:12138091 | lifeskim:mentions | umls-concept:C1996904 | lld:lifeskim |
pubmed-article:12138091 | lifeskim:mentions | umls-concept:C0243144 | lld:lifeskim |
pubmed-article:12138091 | lifeskim:mentions | umls-concept:C0456387 | lld:lifeskim |
pubmed-article:12138091 | lifeskim:mentions | umls-concept:C1880497 | lld:lifeskim |
pubmed-article:12138091 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
pubmed-article:12138091 | pubmed:issue | 39 | lld:pubmed |
pubmed-article:12138091 | pubmed:dateCreated | 2002-9-23 | lld:pubmed |
pubmed-article:12138091 | pubmed:abstractText | The Class B type I scavenger receptor I (SR-BI) is a physiologically relevant high density lipoprotein (HDL) receptor that can mediate selective cholesteryl ester (CE) uptake by cells. Direct interaction of apolipoprotein E (apoE) with this receptor has never been demonstrated, and its implication in CE uptake is still controversial. By using a human adrenal cell line (NCI-H295R), we have addressed the role of apoE in binding to SR-BI and in selective CE uptake from lipoproteins to cells. This cell line does not secrete apoE and SR-BI is its major HDL-binding protein. We can now provide evidence that 1) free apoE is a ligand for SR-BI, 2) apoE associated to lipids or in lipoproteins does not modulate binding or CE-selective uptake by the SR-BI pathway, and 3) the direct interaction of free apoE to SR-BI leads to an increase in CE uptake from lipoproteins of both low and high densities. We propose that this direct interaction could modify SR-BI structure in cell membranes and potentiate CE uptake. | lld:pubmed |
pubmed-article:12138091 | pubmed:language | eng | lld:pubmed |
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pubmed-article:12138091 | pubmed:citationSubset | IM | lld:pubmed |
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pubmed-article:12138091 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:12138091 | pubmed:month | Sep | lld:pubmed |
pubmed-article:12138091 | pubmed:issn | 0021-9258 | lld:pubmed |
pubmed-article:12138091 | pubmed:author | pubmed-author:SiestGérardG | lld:pubmed |
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pubmed-article:12138091 | pubmed:author | pubmed-author:TailleuxAnneA | lld:pubmed |
pubmed-article:12138091 | pubmed:author | pubmed-author:ClaveyVéroniq... | lld:pubmed |
pubmed-article:12138091 | pubmed:author | pubmed-author:Bultel-Brienn... | lld:pubmed |
pubmed-article:12138091 | pubmed:author | pubmed-author:PilonAntoineA | lld:pubmed |
pubmed-article:12138091 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:12138091 | pubmed:day | 27 | lld:pubmed |
pubmed-article:12138091 | pubmed:volume | 277 | lld:pubmed |
pubmed-article:12138091 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:12138091 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:12138091 | pubmed:pagination | 36092-9 | lld:pubmed |
pubmed-article:12138091 | pubmed:dateRevised | 2005-11-17 | lld:pubmed |
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pubmed-article:12138091 | pubmed:year | 2002 | lld:pubmed |
pubmed-article:12138091 | pubmed:articleTitle | Lipid free apolipoprotein E binds to the class B Type I scavenger receptor I (SR-BI) and enhances cholesteryl ester uptake from lipoproteins. | lld:pubmed |
pubmed-article:12138091 | pubmed:affiliation | Unité INSERM U 545, Institut Pasteur de Lille, Faculté de Pharmacie, Université Lille 2, 1 rue du Professeur Calmette, 59019 Lille cedex, France. | lld:pubmed |
pubmed-article:12138091 | pubmed:publicationType | Journal Article | lld:pubmed |
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