| pubmed-article:12134160 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12134160 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:12134160 | lifeskim:mentions | umls-concept:C1413791 | lld:lifeskim |
| pubmed-article:12134160 | lifeskim:mentions | umls-concept:C0040690 | lld:lifeskim |
| pubmed-article:12134160 | lifeskim:mentions | umls-concept:C0018284 | lld:lifeskim |
| pubmed-article:12134160 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:12134160 | lifeskim:mentions | umls-concept:C0279266 | lld:lifeskim |
| pubmed-article:12134160 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:12134160 | pubmed:dateCreated | 2002-7-31 | lld:pubmed |
| pubmed-article:12134160 | pubmed:abstractText | Connective-tissue growth factor (CTGF) is a secreted protein implicated in multiple cellular events including angiogenesis, skeletogenesis and wound healing. It is a member of the CCN family of secreted proteins, named after CTGF, cysteine-rich 61 (CYR61), and nephroblastoma overexpressed (NOV) proteins. The molecular mechanism by which CTGF or other CCN proteins regulate cell signalling is not known. CTGF contains a cysteine-rich domain (CR) similar to those found in chordin and other secreted proteins, which in some cases have been reported to function as bone morphogenetic protein (BMP) and TGF-beta binding domains. Here we show that CTGF directly binds BMP4 and TGF-beta 1 through its CR domain. CTGF can antagonize BMP4 activity by preventing its binding to BMP receptors and has the opposite effect, enhancement of receptor binding, on TGF-beta 1. These results show that CTGF inhibits BMP and activates TGF-beta signals by direct binding in the extracellular space. | lld:pubmed |
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| pubmed-article:12134160 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12134160 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12134160 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12134160 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12134160 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:12134160 | pubmed:issn | 1465-7392 | lld:pubmed |
| pubmed-article:12134160 | pubmed:author | pubmed-author:De... | lld:pubmed |
| pubmed-article:12134160 | pubmed:author | pubmed-author:AbreuJosé GJG | lld:pubmed |
| pubmed-article:12134160 | pubmed:author | pubmed-author:KetpuraNan... | lld:pubmed |
| pubmed-article:12134160 | pubmed:author | pubmed-author:ReversadeBrun... | lld:pubmed |
| pubmed-article:12134160 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12134160 | pubmed:volume | 4 | lld:pubmed |
| pubmed-article:12134160 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12134160 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12134160 | pubmed:pagination | 599-604 | lld:pubmed |
| pubmed-article:12134160 | pubmed:dateRevised | 2011-2-9 | lld:pubmed |
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| pubmed-article:12134160 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12134160 | pubmed:articleTitle | Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-beta. | lld:pubmed |
| pubmed-article:12134160 | pubmed:affiliation | Howard Hughes Medical Institute and Department of Biological Chemistry, University of California, Riverside, 9095-1662, USA. | lld:pubmed |
| pubmed-article:12134160 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12134160 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12134160 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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