Linked Life Data

12134142

Source:http://linkedlifedata.com/resource/pubmed/id/12134142

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:12134142rdf:typepubmed:Citationlld:pubmed
pubmed-article:12134142lifeskim:mentionsumls-concept:C0018787lld:lifeskim
pubmed-article:12134142lifeskim:mentionsumls-concept:C0070876lld:lifeskim
pubmed-article:12134142lifeskim:mentionsumls-concept:C0449258lld:lifeskim
pubmed-article:12134142lifeskim:mentionsumls-concept:C0596988lld:lifeskim
pubmed-article:12134142lifeskim:mentionsumls-concept:C1524066lld:lifeskim
pubmed-article:12134142lifeskim:mentionsumls-concept:C0205191lld:lifeskim
pubmed-article:12134142lifeskim:mentionsumls-concept:C1515655lld:lifeskim
pubmed-article:12134142lifeskim:mentionsumls-concept:C0301625lld:lifeskim
pubmed-article:12134142pubmed:issue8lld:pubmed
pubmed-article:12134142pubmed:dateCreated2002-8-1lld:pubmed
pubmed-article:12134142pubmed:abstractTextThe feasibility of gene therapy for cardiomyopathy, heart failure and other chronic cardiac muscle diseases is so far unproven. Here, we developed an in vivo recombinant adeno-associated virus (rAAV) transcoronary delivery system that allows stable, high efficiency and relatively cardiac-selective gene expression. We used rAAV to express a pseudophosphorylated mutant of human phospholamban (PLN), a key regulator of cardiac sarcoplasmic reticulum (SR) Ca(2+) cycling in BIO14.6 cardiomyopathic hamsters. The rAAV/S16EPLN treatment enhanced myocardial SR Ca(2+) uptake and suppressed progressive impairment of left ventricular (LV) systolic function and contractility for 28-30 weeks, thereby protecting cardiac myocytes from cytopathic plasma-membrane disruption. Low LV systolic pressure and deterioration in LV relaxation were also largely prevented by rAAV/S16EPLN treatment. Thus, transcoronary gene transfer of S16EPLN via rAAV vector is a potential therapy for progressive dilated cardiomyopathy and associated heart failure.lld:pubmed
pubmed-article:12134142pubmed:languageenglld:pubmed
pubmed-article:12134142pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12134142pubmed:citationSubsetIMlld:pubmed
pubmed-article:12134142pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12134142pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12134142pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12134142pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12134142pubmed:statusMEDLINElld:pubmed
pubmed-article:12134142pubmed:monthAuglld:pubmed
pubmed-article:12134142pubmed:issn1078-8956lld:pubmed
pubmed-article:12134142pubmed:authorpubmed-author:GuYusuYlld:pubmed
pubmed-article:12134142pubmed:authorpubmed-author:RossJohnJJrlld:pubmed
pubmed-article:12134142pubmed:authorpubmed-author:WilsonJames...lld:pubmed
pubmed-article:12134142pubmed:authorpubmed-author:ChienKenneth...lld:pubmed
pubmed-article:12134142pubmed:authorpubmed-author:IkedaYasuhiro...lld:pubmed
pubmed-article:12134142pubmed:authorpubmed-author:IwanagaYoshit...lld:pubmed
pubmed-article:12134142pubmed:authorpubmed-author:MinamisawaSus...lld:pubmed
pubmed-article:12134142pubmed:authorpubmed-author:HoshijimaMasa...lld:pubmed
pubmed-article:12134142pubmed:authorpubmed-author:WangYibinYlld:pubmed
pubmed-article:12134142pubmed:authorpubmed-author:WangLiliLlld:pubmed
pubmed-article:12134142pubmed:authorpubmed-author:DateMoto-oMOlld:pubmed
pubmed-article:12134142pubmed:authorpubmed-author:IwatateMitsuo...lld:pubmed
pubmed-article:12134142pubmed:authorpubmed-author:LiManxiangMlld:pubmed
pubmed-article:12134142pubmed:issnTypePrintlld:pubmed
pubmed-article:12134142pubmed:volume8lld:pubmed
pubmed-article:12134142pubmed:ownerNLMlld:pubmed
pubmed-article:12134142pubmed:authorsCompleteYlld:pubmed
pubmed-article:12134142pubmed:pagination864-71lld:pubmed
pubmed-article:12134142pubmed:dateRevised2007-11-15lld:pubmed
pubmed-article:12134142pubmed:meshHeadingpubmed-meshheading:12134142...lld:pubmed
pubmed-article:12134142pubmed:meshHeadingpubmed-meshheading:12134142...lld:pubmed
pubmed-article:12134142pubmed:meshHeadingpubmed-meshheading:12134142...lld:pubmed
pubmed-article:12134142pubmed:meshHeadingpubmed-meshheading:12134142...lld:pubmed
pubmed-article:12134142pubmed:meshHeadingpubmed-meshheading:12134142...lld:pubmed
pubmed-article:12134142pubmed:meshHeadingpubmed-meshheading:12134142...lld:pubmed
pubmed-article:12134142pubmed:meshHeadingpubmed-meshheading:12134142...lld:pubmed
pubmed-article:12134142pubmed:meshHeadingpubmed-meshheading:12134142...lld:pubmed
pubmed-article:12134142pubmed:meshHeadingpubmed-meshheading:12134142...lld:pubmed
pubmed-article:12134142pubmed:meshHeadingpubmed-meshheading:12134142...lld:pubmed
pubmed-article:12134142pubmed:meshHeadingpubmed-meshheading:12134142...lld:pubmed
pubmed-article:12134142pubmed:meshHeadingpubmed-meshheading:12134142...lld:pubmed
pubmed-article:12134142pubmed:meshHeadingpubmed-meshheading:12134142...lld:pubmed
pubmed-article:12134142pubmed:meshHeadingpubmed-meshheading:12134142...lld:pubmed
pubmed-article:12134142pubmed:meshHeadingpubmed-meshheading:12134142...lld:pubmed
pubmed-article:12134142pubmed:meshHeadingpubmed-meshheading:12134142...lld:pubmed
pubmed-article:12134142pubmed:meshHeadingpubmed-meshheading:12134142...lld:pubmed
pubmed-article:12134142pubmed:meshHeadingpubmed-meshheading:12134142...lld:pubmed
pubmed-article:12134142pubmed:meshHeadingpubmed-meshheading:12134142...lld:pubmed
pubmed-article:12134142pubmed:meshHeadingpubmed-meshheading:12134142...lld:pubmed
pubmed-article:12134142pubmed:meshHeadingpubmed-meshheading:12134142...lld:pubmed
pubmed-article:12134142pubmed:meshHeadingpubmed-meshheading:12134142...lld:pubmed
pubmed-article:12134142pubmed:meshHeadingpubmed-meshheading:12134142...lld:pubmed
pubmed-article:12134142pubmed:year2002lld:pubmed
pubmed-article:12134142pubmed:articleTitleChronic suppression of heart-failure progression by a pseudophosphorylated mutant of phospholamban via in vivo cardiac rAAV gene delivery.lld:pubmed
pubmed-article:12134142pubmed:affiliationUniversity of California, San Diego Institute of Molecular Medicine, La Jolla, California, USA.lld:pubmed
pubmed-article:12134142pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:12134142pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12134142lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12134142lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12134142lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12134142lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12134142lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12134142lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12134142lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12134142lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12134142lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12134142lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12134142lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12134142lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12134142lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12134142lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12134142lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12134142lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12134142lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12134142lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12134142lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12134142lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12134142lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12134142lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12134142lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12134142lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12134142lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12134142lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12134142lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12134142lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12134142lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12134142lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12134142lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12134142lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12134142lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12134142lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12134142lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12134142lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12134142lld:pubmed
More...