| pubmed-article:12130749 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12130749 | lifeskim:mentions | umls-concept:C0449738 | lld:lifeskim |
| pubmed-article:12130749 | lifeskim:mentions | umls-concept:C0005854 | lld:lifeskim |
| pubmed-article:12130749 | lifeskim:mentions | umls-concept:C0005528 | lld:lifeskim |
| pubmed-article:12130749 | lifeskim:mentions | umls-concept:C0911014 | lld:lifeskim |
| pubmed-article:12130749 | lifeskim:mentions | umls-concept:C0678594 | lld:lifeskim |
| pubmed-article:12130749 | lifeskim:mentions | umls-concept:C0439792 | lld:lifeskim |
| pubmed-article:12130749 | lifeskim:mentions | umls-concept:C0205225 | lld:lifeskim |
| pubmed-article:12130749 | lifeskim:mentions | umls-concept:C1710548 | lld:lifeskim |
| pubmed-article:12130749 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:12130749 | pubmed:dateCreated | 2002-7-19 | lld:pubmed |
| pubmed-article:12130749 | pubmed:abstractText | The novel hormone ghrelin is a potent orexigen that may counterbalance leptin. Ghrelin is the only secreted molecule requiring post-translational acylation with octanoic acid to ensure bioactivity. Ghrelin, predominantly derived from the stomach, may target neuroendocrine networks within the central nervous system (CNS) to regulate energy homeostasis. This would require ghrelin to cross the blood-brain barrier (BBB). In mice, we examined whether ghrelin crosses the BBB and whether its lipophilic side chain is involved in this process. We found that saturable systems transported human ghrelin from brain-to-blood and from blood-to-brain. Mouse ghrelin, differing from human ghrelin by two amino acids, was a substrate for the brain-to-blood but not for the blood-to-brain transporter and so entered the brain to a far lesser degree. des-Octanoyl ghrelin entered the brain by nonsaturable transmembrane diffusion and was sequestered once within the CNS. In summary, we show that ghrelin transport across the BBB is a complex, highly regulated bidirectional process. The direction and extent of passage are determined by the primary structure of ghrelin, defining a new role for the unique post-translational octanoylation. | lld:pubmed |
| pubmed-article:12130749 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12130749 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12130749 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12130749 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12130749 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12130749 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12130749 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12130749 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12130749 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12130749 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:12130749 | pubmed:issn | 0022-3565 | lld:pubmed |
| pubmed-article:12130749 | pubmed:author | pubmed-author:TschöpMatthia... | lld:pubmed |
| pubmed-article:12130749 | pubmed:author | pubmed-author:HeimanMark... | lld:pubmed |
| pubmed-article:12130749 | pubmed:author | pubmed-author:BanksWilliam... | lld:pubmed |
| pubmed-article:12130749 | pubmed:author | pubmed-author:RobinsonSandr... | lld:pubmed |
| pubmed-article:12130749 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12130749 | pubmed:volume | 302 | lld:pubmed |
| pubmed-article:12130749 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12130749 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12130749 | pubmed:pagination | 822-7 | lld:pubmed |
| pubmed-article:12130749 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:12130749 | pubmed:meshHeading | pubmed-meshheading:12130749... | lld:pubmed |
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| pubmed-article:12130749 | pubmed:meshHeading | pubmed-meshheading:12130749... | lld:pubmed |
| pubmed-article:12130749 | pubmed:meshHeading | pubmed-meshheading:12130749... | lld:pubmed |
| pubmed-article:12130749 | pubmed:meshHeading | pubmed-meshheading:12130749... | lld:pubmed |
| pubmed-article:12130749 | pubmed:meshHeading | pubmed-meshheading:12130749... | lld:pubmed |
| pubmed-article:12130749 | pubmed:meshHeading | pubmed-meshheading:12130749... | lld:pubmed |
| pubmed-article:12130749 | pubmed:meshHeading | pubmed-meshheading:12130749... | lld:pubmed |
| pubmed-article:12130749 | pubmed:meshHeading | pubmed-meshheading:12130749... | lld:pubmed |
| pubmed-article:12130749 | pubmed:meshHeading | pubmed-meshheading:12130749... | lld:pubmed |
| pubmed-article:12130749 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12130749 | pubmed:articleTitle | Extent and direction of ghrelin transport across the blood-brain barrier is determined by its unique primary structure. | lld:pubmed |
| pubmed-article:12130749 | pubmed:affiliation | The Geriatric Research, Education, and Clinical Center, Veterans Affairs Medical Center-St. Louis, 915 N Grand Boulevard, St. Louis, MO, USA. bankswa@slu.edu | lld:pubmed |
| pubmed-article:12130749 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12130749 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12130749 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:12130749 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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