| pubmed-article:12127525 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12127525 | lifeskim:mentions | umls-concept:C0205103 | lld:lifeskim |
| pubmed-article:12127525 | lifeskim:mentions | umls-concept:C0070829 | lld:lifeskim |
| pubmed-article:12127525 | lifeskim:mentions | umls-concept:C0311400 | lld:lifeskim |
| pubmed-article:12127525 | lifeskim:mentions | umls-concept:C1167622 | lld:lifeskim |
| pubmed-article:12127525 | lifeskim:mentions | umls-concept:C0205332 | lld:lifeskim |
| pubmed-article:12127525 | lifeskim:mentions | umls-concept:C0205360 | lld:lifeskim |
| pubmed-article:12127525 | lifeskim:mentions | umls-concept:C0054858 | lld:lifeskim |
| pubmed-article:12127525 | lifeskim:mentions | umls-concept:C1511539 | lld:lifeskim |
| pubmed-article:12127525 | lifeskim:mentions | umls-concept:C0332256 | lld:lifeskim |
| pubmed-article:12127525 | lifeskim:mentions | umls-concept:C1708528 | lld:lifeskim |
| pubmed-article:12127525 | lifeskim:mentions | umls-concept:C0243077 | lld:lifeskim |
| pubmed-article:12127525 | lifeskim:mentions | umls-concept:C1522492 | lld:lifeskim |
| pubmed-article:12127525 | lifeskim:mentions | umls-concept:C1272745 | lld:lifeskim |
| pubmed-article:12127525 | pubmed:issue | 16 | lld:pubmed |
| pubmed-article:12127525 | pubmed:dateCreated | 2002-7-19 | lld:pubmed |
| pubmed-article:12127525 | pubmed:abstractText | A detailed study directed towards metabolic stability optimization of the alkoxy substituents on the catechol moiety of CDP-840 is reported. Replacement of the methoxy and cyclopentyloxy substituents by cyclobutyloxy and/or difluromethoxy groups resulted in the discovery of potent and selective PDE4 inhibitors where the formation of reactive metabolites that could covalently bind to microsomal protein was significantly reduced or eliminated. | lld:pubmed |
| pubmed-article:12127525 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12127525 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12127525 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12127525 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12127525 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12127525 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12127525 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12127525 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12127525 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12127525 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12127525 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:12127525 | pubmed:issn | 0960-894X | lld:pubmed |
| pubmed-article:12127525 | pubmed:author | pubmed-author:EschJ FJF | lld:pubmed |
| pubmed-article:12127525 | pubmed:author | pubmed-author:GuayDanielD | lld:pubmed |
| pubmed-article:12127525 | pubmed:author | pubmed-author:BlouinMarcM | lld:pubmed |
| pubmed-article:12127525 | pubmed:author | pubmed-author:ChauretNathal... | lld:pubmed |
| pubmed-article:12127525 | pubmed:author | pubmed-author:DucharmeYvesY | lld:pubmed |
| pubmed-article:12127525 | pubmed:author | pubmed-author:SilvaJoséJ | lld:pubmed |
| pubmed-article:12127525 | pubmed:author | pubmed-author:DayStephenS | lld:pubmed |
| pubmed-article:12127525 | pubmed:author | pubmed-author:YergeyJames... | lld:pubmed |
| pubmed-article:12127525 | pubmed:author | pubmed-author:Nicoll-Griffi... | lld:pubmed |
| pubmed-article:12127525 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12127525 | pubmed:day | 19 | lld:pubmed |
| pubmed-article:12127525 | pubmed:volume | 12 | lld:pubmed |
| pubmed-article:12127525 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12127525 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12127525 | pubmed:pagination | 2149-52 | lld:pubmed |
| pubmed-article:12127525 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:12127525 | pubmed:meshHeading | pubmed-meshheading:12127525... | lld:pubmed |
| pubmed-article:12127525 | pubmed:meshHeading | pubmed-meshheading:12127525... | lld:pubmed |
| pubmed-article:12127525 | pubmed:meshHeading | pubmed-meshheading:12127525... | lld:pubmed |
| pubmed-article:12127525 | pubmed:meshHeading | pubmed-meshheading:12127525... | lld:pubmed |
| pubmed-article:12127525 | pubmed:meshHeading | pubmed-meshheading:12127525... | lld:pubmed |
| pubmed-article:12127525 | pubmed:meshHeading | pubmed-meshheading:12127525... | lld:pubmed |
| pubmed-article:12127525 | pubmed:meshHeading | pubmed-meshheading:12127525... | lld:pubmed |
| pubmed-article:12127525 | pubmed:meshHeading | pubmed-meshheading:12127525... | lld:pubmed |
| pubmed-article:12127525 | pubmed:meshHeading | pubmed-meshheading:12127525... | lld:pubmed |
| pubmed-article:12127525 | pubmed:meshHeading | pubmed-meshheading:12127525... | lld:pubmed |
| pubmed-article:12127525 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12127525 | pubmed:articleTitle | Improving metabolic stability of phosphodiesterase-4 inhibitors containing a substituted catechol: prevention of reactive intermediate formation and covalent binding. | lld:pubmed |
| pubmed-article:12127525 | pubmed:affiliation | Merck Frosst Centre for Therapeutic Research, PO Box 1005, Pointe Claire-Dorval, H9R 4P8, Québec, Canada. nathalie_chauret@merk.com | lld:pubmed |
| pubmed-article:12127525 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:12127525 | lld:chembl |
