| pubmed-article:12119411 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12119411 | lifeskim:mentions | umls-concept:C0936090 | lld:lifeskim |
| pubmed-article:12119411 | lifeskim:mentions | umls-concept:C1521991 | lld:lifeskim |
| pubmed-article:12119411 | lifeskim:mentions | umls-concept:C1817706 | lld:lifeskim |
| pubmed-article:12119411 | lifeskim:mentions | umls-concept:C0376644 | lld:lifeskim |
| pubmed-article:12119411 | pubmed:issue | 15 | lld:pubmed |
| pubmed-article:12119411 | pubmed:dateCreated | 2002-7-24 | lld:pubmed |
| pubmed-article:12119411 | pubmed:abstractText | In an attempt to characterize early B cell development including the commitment of progenitor cells to the B cell lineage, we generated and compared genomewide gene expression profiles of human hematopoietic stem cells (HSCs) and pre-B cells (PBCs) by using serial analysis of gene expression. From more than 100,000 serial analysis of gene expression tags collected from human CD34(+) HSCs and CD10(+) CD19(+) PBCs, 42,399 unique transcripts were identified in HSCs but only 16,786 in PBCs, suggesting that more than 60% of transcripts expressed in HSCs were silenced during or after commitment to the B cell lineage. On the other hand, mRNAs of pre-B cell receptor (pre-BCR)-associated genes are virtually missing in HSCs but account for more than 10% of the transcriptome of PBCs, which also show increased expression of apoptosis-related genes. Both concentration of the transcriptional repertoire on pre-BCR-related genes together with marked up-regulation of apoptosis mediators in PBC might reflect selection for the expression of a functional pre-BCR within the bone marrow. Besides known regulator genes of early B cell development such as PAX5, E2A, and EBF, the most abundantly expressed genes in PBCs include ATM, PDGFRA, SIAH1, PIM2, C/EBPB, WNT16, and TCL1, the role of which has not been established yet in early B cell development. | lld:pubmed |
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| pubmed-article:12119411 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:12119411 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12119411 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12119411 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:12119411 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:12119411 | pubmed:author | pubmed-author:ChenJianjunJ | lld:pubmed |
| pubmed-article:12119411 | pubmed:author | pubmed-author:LeeSanggyuS | lld:pubmed |
| pubmed-article:12119411 | pubmed:author | pubmed-author:ZhouGuolinG | lld:pubmed |
| pubmed-article:12119411 | pubmed:author | pubmed-author:WangSan... | lld:pubmed |
| pubmed-article:12119411 | pubmed:author | pubmed-author:RowleyJanet... | lld:pubmed |
| pubmed-article:12119411 | pubmed:author | pubmed-author:MüschenMarkus... | lld:pubmed |
| pubmed-article:12119411 | pubmed:author | pubmed-author:KrönkeMartinM | lld:pubmed |
| pubmed-article:12119411 | pubmed:author | pubmed-author:FeldhahnNikla... | lld:pubmed |
| pubmed-article:12119411 | pubmed:author | pubmed-author:BarathVarun... | lld:pubmed |
| pubmed-article:12119411 | pubmed:author | pubmed-author:MoersCordulaC | lld:pubmed |
| pubmed-article:12119411 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12119411 | pubmed:day | 23 | lld:pubmed |
| pubmed-article:12119411 | pubmed:volume | 99 | lld:pubmed |
| pubmed-article:12119411 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12119411 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12119411 | pubmed:pagination | 10014-9 | lld:pubmed |
| pubmed-article:12119411 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:12119411 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12119411 | pubmed:articleTitle | Molecular portraits of B cell lineage commitment. | lld:pubmed |
| pubmed-article:12119411 | pubmed:affiliation | Institute for Genetics, University of Cologne, Weyertal 121, 50931 Cologne, Germany. markus.mueschen@uni-koeln.de | lld:pubmed |
| pubmed-article:12119411 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12119411 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12119411 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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