| pubmed-article:12119393 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12119393 | lifeskim:mentions | umls-concept:C0007301 | lld:lifeskim |
| pubmed-article:12119393 | lifeskim:mentions | umls-concept:C0015350 | lld:lifeskim |
| pubmed-article:12119393 | lifeskim:mentions | umls-concept:C0225369 | lld:lifeskim |
| pubmed-article:12119393 | lifeskim:mentions | umls-concept:C0043240 | lld:lifeskim |
| pubmed-article:12119393 | lifeskim:mentions | umls-concept:C0007590 | lld:lifeskim |
| pubmed-article:12119393 | lifeskim:mentions | umls-concept:C0030956 | lld:lifeskim |
| pubmed-article:12119393 | lifeskim:mentions | umls-concept:C0063083 | lld:lifeskim |
| pubmed-article:12119393 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:12119393 | pubmed:issue | 15 | lld:pubmed |
| pubmed-article:12119393 | pubmed:dateCreated | 2002-7-24 | lld:pubmed |
| pubmed-article:12119393 | pubmed:abstractText | Emerging medical technologies for effective and lasting repair of articular cartilage include delivery of cells or cell-seeded scaffolds to a defect site to initiate de novo tissue regeneration. Biocompatible scaffolds assist in providing a template for cell distribution and extracellular matrix (ECM) accumulation in a three-dimensional geometry. A major challenge in choosing an appropriate scaffold for cartilage repair is the identification of a material that can simultaneously stimulate high rates of cell division and high rates of cell synthesis of phenotypically specific ECM macromolecules until repair evolves into steady-state tissue maintenance. We have devised a self-assembling peptide hydrogel scaffold for cartilage repair and developed a method to encapsulate chondrocytes within the peptide hydrogel. During 4 weeks of culture in vitro, chondrocytes seeded within the peptide hydrogel retained their morphology and developed a cartilage-like ECM rich in proteoglycans and type II collagen, indicative of a stable chondrocyte phenotype. Time-dependent accumulation of this ECM was paralleled by increases in material stiffness, indicative of deposition of mechanically functional neo-tissue. Taken together, these results demonstrate the potential of a self-assembling peptide hydrogel as a scaffold for the synthesis and accumulation of a true cartilage-like ECM within a three-dimensional cell culture for cartilage tissue repair. | lld:pubmed |
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| pubmed-article:12119393 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12119393 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12119393 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12119393 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12119393 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:12119393 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:12119393 | pubmed:author | pubmed-author:GrodzinskyA... | lld:pubmed |
| pubmed-article:12119393 | pubmed:author | pubmed-author:KurzBB | lld:pubmed |
| pubmed-article:12119393 | pubmed:author | pubmed-author:ZhangSS | lld:pubmed |
| pubmed-article:12119393 | pubmed:author | pubmed-author:JinMM | lld:pubmed |
| pubmed-article:12119393 | pubmed:author | pubmed-author:HundMM | lld:pubmed |
| pubmed-article:12119393 | pubmed:author | pubmed-author:SeminiEE | lld:pubmed |
| pubmed-article:12119393 | pubmed:author | pubmed-author:KisidayJJ | lld:pubmed |
| pubmed-article:12119393 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12119393 | pubmed:day | 23 | lld:pubmed |
| pubmed-article:12119393 | pubmed:volume | 99 | lld:pubmed |
| pubmed-article:12119393 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12119393 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12119393 | pubmed:pagination | 9996-10001 | lld:pubmed |
| pubmed-article:12119393 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:12119393 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12119393 | pubmed:articleTitle | Self-assembling peptide hydrogel fosters chondrocyte extracellular matrix production and cell division: implications for cartilage tissue repair. | lld:pubmed |
| pubmed-article:12119393 | pubmed:affiliation | Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, MA 02139-4307, USA. | lld:pubmed |
| pubmed-article:12119393 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12119393 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12119393 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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