| pubmed-article:12119348 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12119348 | lifeskim:mentions | umls-concept:C1704256 | lld:lifeskim |
| pubmed-article:12119348 | lifeskim:mentions | umls-concept:C0039198 | lld:lifeskim |
| pubmed-article:12119348 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:12119348 | lifeskim:mentions | umls-concept:C0332197 | lld:lifeskim |
| pubmed-article:12119348 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:12119348 | lifeskim:mentions | umls-concept:C1334114 | lld:lifeskim |
| pubmed-article:12119348 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:12119348 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:12119348 | lifeskim:mentions | umls-concept:C2003905 | lld:lifeskim |
| pubmed-article:12119348 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:12119348 | pubmed:dateCreated | 2002-7-16 | lld:pubmed |
| pubmed-article:12119348 | pubmed:abstractText | CD4(+)CD25(+) regulatory T cells inhibit organ-specific autoimmune diseases induced by CD4(+)CD25(-) T cells and are potent suppressors of T cell activation in vitro. Their mechanism of suppression remains unknown, but most in vitro studies suggest that it is cell contact-dependent and cytokine independent. The role of TGF-beta1 in CD4(+)CD25(+) suppressor function remains unclear. While most studies have failed to reverse suppression with anti-transforming growth factor (TGF)-beta1 in vitro, one recent study has reported that CD4(+)CD25(+) T cells express cell surface TGF-beta1 and that suppression can be completely abrogated by high concentrations of anti-TGF-beta suggesting that cell-associated TGF-beta1 was the primary effector of CD4(+)CD25(+)-mediated suppression. Here, we have reevaluated the role of TGF-beta1 in CD4(+)CD25(+)-mediated suppression. Neutralization of TGF-beta1 with either monoclonal antibody (mAb) or soluble TGF-betaRII-Fc did not reverse in vitro suppression mediated by resting or activated CD4(+)CD25(+) T cells. Responder T cells from Smad3(-/-) or dominant-negative TGF-beta type RII transgenic (DNRIITg) mice, that are both unresponsive to TGF-beta1-induced growth arrest, were as susceptible to CD4(+)CD25(+)-mediated suppression as T cells from wild-type mice. Furthermore, CD4(+)CD25(+) T cells from neonatal TGF-beta1(-/-) mice were as suppressive as CD4(+)CD25(+) from TGF-beta1(+/+) mice. Collectively, these results demonstrate that CD4(+)CD25(+) suppressor function can occur independently of TGF-beta1. | lld:pubmed |
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| pubmed-article:12119348 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12119348 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12119348 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12119348 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12119348 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12119348 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:12119348 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:12119348 | pubmed:author | pubmed-author:ShevachEthan... | lld:pubmed |
| pubmed-article:12119348 | pubmed:author | pubmed-author:MamuraMizukoM | lld:pubmed |
| pubmed-article:12119348 | pubmed:author | pubmed-author:McHughRebecca... | lld:pubmed |
| pubmed-article:12119348 | pubmed:author | pubmed-author:PiccirilloCir... | lld:pubmed |
| pubmed-article:12119348 | pubmed:author | pubmed-author:LetterioJohn... | lld:pubmed |
| pubmed-article:12119348 | pubmed:author | pubmed-author:ThorntonAngel... | lld:pubmed |
| pubmed-article:12119348 | pubmed:author | pubmed-author:MizuharaHidek... | lld:pubmed |
| pubmed-article:12119348 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12119348 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:12119348 | pubmed:volume | 196 | lld:pubmed |
| pubmed-article:12119348 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12119348 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12119348 | pubmed:pagination | 237-46 | lld:pubmed |
| pubmed-article:12119348 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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