| pubmed-article:12112858 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12112858 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:12112858 | lifeskim:mentions | umls-concept:C0038172 | lld:lifeskim |
| pubmed-article:12112858 | lifeskim:mentions | umls-concept:C0080194 | lld:lifeskim |
| pubmed-article:12112858 | lifeskim:mentions | umls-concept:C0012632 | lld:lifeskim |
| pubmed-article:12112858 | lifeskim:mentions | umls-concept:C2610507 | lld:lifeskim |
| pubmed-article:12112858 | lifeskim:mentions | umls-concept:C0037813 | lld:lifeskim |
| pubmed-article:12112858 | lifeskim:mentions | umls-concept:C0023089 | lld:lifeskim |
| pubmed-article:12112858 | lifeskim:mentions | umls-concept:C1555977 | lld:lifeskim |
| pubmed-article:12112858 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:12112858 | pubmed:dateCreated | 2002-7-11 | lld:pubmed |
| pubmed-article:12112858 | pubmed:abstractText | Staphylococcus aureus is an important human pathogen frequently resistant to a wide range of antibiotics. Methicillin-resistant S. aureus (MRSA) strains are common nosocomial pathogens that pose a world-wide problem. Rapid and accurate discrimination between methicillin-sensitive S. aureus (MSSA) and methicillin-resistant S. aureus is essential for appropriate therapeutic management and timely intervention for infection control. We report here the application of matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF MS) for monitoring the bacterial fingerprints expressed by two well characterized S. aureus strains ATCC 29213 (MSSA) and ATCC 43330 (MRSA). Consistent strain-specific data were obtained from subcultures analyzed over a period of three months as well as after changing the growth media from Mueller-Hinton to blood agar indicating the reliability of the method. The bacterial fingerprints of these two strains were compared to independent clinical isolates of S. aureus. A uniform signature profile for MRSA could not be identified. However, the bacterial fingerprints obtained proved to be specific for any given strain. This study demonstrates that MALDI-TOF MS is a powerful method for rapid identification of clonal strains of S. aureus, which might be useful for tracking nosocomial outbreaks of MRSA and for epidemiologic studies of infections diseases in general. | lld:pubmed |
| pubmed-article:12112858 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12112858 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12112858 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12112858 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12112858 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12112858 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:12112858 | pubmed:issn | 1615-9853 | lld:pubmed |
| pubmed-article:12112858 | pubmed:author | pubmed-author:SeifertHarald... | lld:pubmed |
| pubmed-article:12112858 | pubmed:author | pubmed-author:KrönkeMartinM | lld:pubmed |
| pubmed-article:12112858 | pubmed:author | pubmed-author:BernardoKatus... | lld:pubmed |
| pubmed-article:12112858 | pubmed:author | pubmed-author:FleerSilkeS | lld:pubmed |
| pubmed-article:12112858 | pubmed:author | pubmed-author:PakulatNorber... | lld:pubmed |
| pubmed-article:12112858 | pubmed:author | pubmed-author:KrutOlegO | lld:pubmed |
| pubmed-article:12112858 | pubmed:author | pubmed-author:HüngerFrankF | lld:pubmed |
| pubmed-article:12112858 | pubmed:author | pubmed-author:MachtMarcusM | lld:pubmed |
| pubmed-article:12112858 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12112858 | pubmed:volume | 2 | lld:pubmed |
| pubmed-article:12112858 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12112858 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12112858 | pubmed:pagination | 747-53 | lld:pubmed |
| pubmed-article:12112858 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
| pubmed-article:12112858 | pubmed:meshHeading | pubmed-meshheading:12112858... | lld:pubmed |
| pubmed-article:12112858 | pubmed:meshHeading | pubmed-meshheading:12112858... | lld:pubmed |
| pubmed-article:12112858 | pubmed:meshHeading | pubmed-meshheading:12112858... | lld:pubmed |
| pubmed-article:12112858 | pubmed:meshHeading | pubmed-meshheading:12112858... | lld:pubmed |
| pubmed-article:12112858 | pubmed:meshHeading | pubmed-meshheading:12112858... | lld:pubmed |
| pubmed-article:12112858 | pubmed:meshHeading | pubmed-meshheading:12112858... | lld:pubmed |
| pubmed-article:12112858 | pubmed:meshHeading | pubmed-meshheading:12112858... | lld:pubmed |
| pubmed-article:12112858 | pubmed:meshHeading | pubmed-meshheading:12112858... | lld:pubmed |
| pubmed-article:12112858 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12112858 | pubmed:articleTitle | Identification and discrimination of Staphylococcus aureus strains using matrix-assisted laser desorption/ionization-time of flight mass spectrometry. | lld:pubmed |
| pubmed-article:12112858 | pubmed:affiliation | Institute of Medical Microbiology, Immunology and Hygiene, Medical Center, University of Cologne, Köln, Germany. aky34@uni-koeln.de | lld:pubmed |
| pubmed-article:12112858 | pubmed:publicationType | Journal Article | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12112858 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12112858 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12112858 | lld:pubmed |
