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pubmed-article:12110027pubmed:abstractTextChronic allograft rejection is the major clinical problem in organ transplantation. There is evidence that indirect T cell recognition of donor-specific HLA peptides may play an important role in the immunopathogenesis of chronic allograft rejection. We have recently shown that HLA allopeptide-specific T cell clones generated from renal transplant recipients with chronic allograft nephropathy are of the Th1 phenotype, while those from stable patients are Th2. There is evidence in experimental animal models of autoimmunity and transplantation that Th2 cells may function to regulate immune responses, but the biological relevance of these observations in humans has not been reported.lld:pubmed
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pubmed-article:12110027pubmed:articleTitleRegulatory functions of alloreactive Th2 clones in human renal transplant recipients.lld:pubmed
pubmed-article:12110027pubmed:affiliationDivision of Nephrology, Children's Hospital, and Renal Division, Laboratory of Immunogenetics and Transplantation, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.lld:pubmed
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