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pubmed-article:12109948pubmed:abstractTextWe describe our experience with plasma exchange (PE) therapy in 13 patients with drug-induced toxic epidermal necrolysis (TEN), 4 of whom had malignant disorders. Skin lesions covered 17% to 100% of total body surface area and 1 to 4 mucous membranes were involved. None of the patients was hospitalized in a burn unit. The patients underwent from 2 to 5 PE sessions (mean 3.4 +/- 0.2 standard error of mean [SEM], median 3) exchanging 6.6 to 17.6 L of plasma (mean 10.1 +/- 0.7 SEM, median 10). PE sessions were carried out every other day in 8 patients and daily in 5. Three patients died (23%) while the remaining 10 (77%) had a full recovery. Plasmapheresis may be an effective treatment in patients with drug-induced TEN hospitalized outside a burn unit.lld:pubmed
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pubmed-article:12109948pubmed:dateRevised2004-11-17lld:pubmed
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pubmed-article:12109948pubmed:articleTitlePlasma exchange in patients with toxic epidermal necrolysis.lld:pubmed
pubmed-article:12109948pubmed:affiliationRenal Unit, General Hospital G. Papanikolaou, Aristotele University of Thessaloniki, Greece.lld:pubmed
pubmed-article:12109948pubmed:publicationTypeJournal Articlelld:pubmed
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