| pubmed-article:12108786 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12108786 | lifeskim:mentions | umls-concept:C0020538 | lld:lifeskim |
| pubmed-article:12108786 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:12108786 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:12108786 | lifeskim:mentions | umls-concept:C1522460 | lld:lifeskim |
| pubmed-article:12108786 | lifeskim:mentions | umls-concept:C0042401 | lld:lifeskim |
| pubmed-article:12108786 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:12108786 | pubmed:dateCreated | 2002-7-10 | lld:pubmed |
| pubmed-article:12108786 | pubmed:abstractText | Tetrahydropapaveroline (THP), a condensation product of ethanol-derived acetaldehyde, has been shown to elicit a vasorelaxant response in rat thoracic aorta. This study examined the influence of hypertension on the THP-induced vasorelaxant responsiveness. Ring segments of thoracic aorta were isolated from Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR) and isometric tension development was measured with a force transducer. In aorta, with or without intact endothelium, the contractile responses to potassium chloride (0-120 mM) were comparable between the WKY and the SHR groups. Hypertension did not affect the vasoconstrictive response to norepinephrine (0-10 microM) in vessels with intact endothelium, whereas it attenuated the norepinephrine-induced response in vessels without endothelium. THP (0.1-100 microM) elicited endothelium-intact as well as -denuded vasorelaxation in aorta from both WKY and SHR groups. Interestingly, the THP-induced endothelium-dependent vasorelaxation was significantly enhanced, whereas the THP-induced endothelium-independent vasorelaxation was not affected by hypertension. These data indicate that the THP-induced endothelium-dependent vasorelaxant response is altered by the hypertensive state. | lld:pubmed |
| pubmed-article:12108786 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12108786 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12108786 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12108786 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12108786 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12108786 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12108786 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12108786 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12108786 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12108786 | pubmed:issn | 0743-5800 | lld:pubmed |
| pubmed-article:12108786 | pubmed:author | pubmed-author:OngY WYW | lld:pubmed |
| pubmed-article:12108786 | pubmed:author | pubmed-author:BrownRicardo... | lld:pubmed |
| pubmed-article:12108786 | pubmed:author | pubmed-author:IlgKarl JKJ | lld:pubmed |
| pubmed-article:12108786 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12108786 | pubmed:volume | 28 | lld:pubmed |
| pubmed-article:12108786 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12108786 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12108786 | pubmed:pagination | 19-26 | lld:pubmed |
| pubmed-article:12108786 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:12108786 | pubmed:meshHeading | pubmed-meshheading:12108786... | lld:pubmed |
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| pubmed-article:12108786 | pubmed:meshHeading | pubmed-meshheading:12108786... | lld:pubmed |
| pubmed-article:12108786 | pubmed:articleTitle | Influence of hypertension on tetrahydropapaveroline-induced vasorelaxation in rat thoracic aorta. | lld:pubmed |
| pubmed-article:12108786 | pubmed:affiliation | Department of Biology, Morgan State University, Baltimore, MD 21251, USA. | lld:pubmed |
| pubmed-article:12108786 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12108786 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
