| pubmed-article:12099691 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12099691 | lifeskim:mentions | umls-concept:C0242383 | lld:lifeskim |
| pubmed-article:12099691 | lifeskim:mentions | umls-concept:C0012854 | lld:lifeskim |
| pubmed-article:12099691 | lifeskim:mentions | umls-concept:C1413931 | lld:lifeskim |
| pubmed-article:12099691 | lifeskim:mentions | umls-concept:C1882417 | lld:lifeskim |
| pubmed-article:12099691 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:12099691 | pubmed:dateCreated | 2002-7-8 | lld:pubmed |
| pubmed-article:12099691 | pubmed:abstractText | Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly. We report an association between an Alu polymorphism in the angiotensin-converting enzyme (ACE) gene with the dry/atrophic form of AMD. Using the polymerase chain reaction (PCR) on genomic DNA isolated from patients with AMD (n=173), and an age-matched control population (n=189), we amplified a region polymorphic for an Alu element insertion in the ACE gene. The Alu(+/+) genotype occurred 4.5 times more frequently in the control population than the dry/atrophic AMD patient population, (p=0.004). The predominance of the Alu(+/+) genotype within the unaffected control group represents a protective insertion with respect to the human ocular disease, dry/atrophic AMD. This is the first demonstration of an Alu element insertion exerting protective effects against a known human disease. | lld:pubmed |
| pubmed-article:12099691 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12099691 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12099691 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12099691 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12099691 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:12099691 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:12099691 | pubmed:author | pubmed-author:NesburnAnthon... | lld:pubmed |
| pubmed-article:12099691 | pubmed:author | pubmed-author:AtilanoShari... | lld:pubmed |
| pubmed-article:12099691 | pubmed:author | pubmed-author:KenneyM... | lld:pubmed |
| pubmed-article:12099691 | pubmed:author | pubmed-author:BrownDonald... | lld:pubmed |
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| pubmed-article:12099691 | pubmed:author | pubmed-author:ReznikJacobJ | lld:pubmed |
| pubmed-article:12099691 | pubmed:author | pubmed-author:OngJohn MJM | lld:pubmed |
| pubmed-article:12099691 | pubmed:author | pubmed-author:UdarNitinN | lld:pubmed |
| pubmed-article:12099691 | pubmed:author | pubmed-author:TavisJeffrey... | lld:pubmed |
| pubmed-article:12099691 | pubmed:author | pubmed-author:BoyerDavid... | lld:pubmed |
| pubmed-article:12099691 | pubmed:author | pubmed-author:SmallKent WKW | lld:pubmed |
| pubmed-article:12099691 | pubmed:copyrightInfo | (c) 2002 Elsevier Science (USA). | lld:pubmed |
| pubmed-article:12099691 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12099691 | pubmed:day | 19 | lld:pubmed |
| pubmed-article:12099691 | pubmed:volume | 295 | lld:pubmed |
| pubmed-article:12099691 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12099691 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12099691 | pubmed:pagination | 668-72 | lld:pubmed |
| pubmed-article:12099691 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:12099691 | pubmed:meshHeading | pubmed-meshheading:12099691... | lld:pubmed |
| pubmed-article:12099691 | pubmed:meshHeading | pubmed-meshheading:12099691... | lld:pubmed |
| pubmed-article:12099691 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12099691 | pubmed:articleTitle | Alu DNA polymorphism in ACE gene is protective for age-related macular degeneration. | lld:pubmed |
| pubmed-article:12099691 | pubmed:affiliation | Department of Surgery, Ophthalmology Research Laboratories, Burns and Allen Research Institute, Cedars-Sinai Medical Center, UCLA Medical School Affiliate, 90048, USA. hkhamdi@aol.com | lld:pubmed |
| pubmed-article:12099691 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12099691 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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