| pubmed-article:12096037 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12096037 | lifeskim:mentions | umls-concept:C0330390 | lld:lifeskim |
| pubmed-article:12096037 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
| pubmed-article:12096037 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
| pubmed-article:12096037 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:12096037 | lifeskim:mentions | umls-concept:C0019629 | lld:lifeskim |
| pubmed-article:12096037 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
| pubmed-article:12096037 | lifeskim:mentions | umls-concept:C0030956 | lld:lifeskim |
| pubmed-article:12096037 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:12096037 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
| pubmed-article:12096037 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
| pubmed-article:12096037 | lifeskim:mentions | umls-concept:C1879748 | lld:lifeskim |
| pubmed-article:12096037 | lifeskim:mentions | umls-concept:C1706853 | lld:lifeskim |
| pubmed-article:12096037 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:12096037 | pubmed:dateCreated | 2002-7-3 | lld:pubmed |
| pubmed-article:12096037 | pubmed:abstractText | Functional MHC class I molecules are expressed on the cell surface in the absence of beta(2)-microglobulin (beta(2)m) light chain that can interact with CD8(+) T lymphocytes. Whether their assembly requires peptide binding and whether their recognition by CD8(+) T lymphocytes involves the presentation of peptide epitopes remains unknown. We show that beta(2)m-free H-2D(b) assembles with short peptides that are approximately 9 amino acid residues in length, akin to ligands associated with completely assembled beta(2)m(+) H-2D(b). Remarkably, a subset of the peptides associated with the beta(2)m-free H-2D(b) has an altered anchor motif. However, they also include peptides that contain a beta(2)m(+)H-2D(b) binding anchor motif. Further, the H-2K(b)- and H-2D(b)-restricted peptide epitopes derived from SV-40 T antigen also assemble with H-2(b) class I in beta(2)m-deficient cells and are recognized by epitope-specific CD8(+) T lymphocytes. Taken together our data reveal that functional MHC class I molecules assemble in the absence of beta(2)m with peptides and form CD8(+) T lymphocyte epitopes. | lld:pubmed |
| pubmed-article:12096037 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12096037 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12096037 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12096037 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12096037 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12096037 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12096037 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12096037 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12096037 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12096037 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12096037 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12096037 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12096037 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:12096037 | pubmed:issn | 0953-8178 | lld:pubmed |
| pubmed-article:12096037 | pubmed:author | pubmed-author:JoyceSebastia... | lld:pubmed |
| pubmed-article:12096037 | pubmed:author | pubmed-author:SchellTodd... | lld:pubmed |
| pubmed-article:12096037 | pubmed:author | pubmed-author:MylinLawrence... | lld:pubmed |
| pubmed-article:12096037 | pubmed:author | pubmed-author:TevethiaSatvi... | lld:pubmed |
| pubmed-article:12096037 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12096037 | pubmed:volume | 14 | lld:pubmed |
| pubmed-article:12096037 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12096037 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12096037 | pubmed:pagination | 775-82 | lld:pubmed |
| pubmed-article:12096037 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:12096037 | pubmed:meshHeading | pubmed-meshheading:12096037... | lld:pubmed |
| pubmed-article:12096037 | pubmed:meshHeading | pubmed-meshheading:12096037... | lld:pubmed |
| pubmed-article:12096037 | pubmed:meshHeading | pubmed-meshheading:12096037... | lld:pubmed |
| pubmed-article:12096037 | pubmed:meshHeading | pubmed-meshheading:12096037... | lld:pubmed |
| pubmed-article:12096037 | pubmed:meshHeading | pubmed-meshheading:12096037... | lld:pubmed |
| pubmed-article:12096037 | pubmed:meshHeading | pubmed-meshheading:12096037... | lld:pubmed |
| pubmed-article:12096037 | pubmed:meshHeading | pubmed-meshheading:12096037... | lld:pubmed |
| pubmed-article:12096037 | pubmed:meshHeading | pubmed-meshheading:12096037... | lld:pubmed |
| pubmed-article:12096037 | pubmed:meshHeading | pubmed-meshheading:12096037... | lld:pubmed |
| pubmed-article:12096037 | pubmed:meshHeading | pubmed-meshheading:12096037... | lld:pubmed |
| pubmed-article:12096037 | pubmed:meshHeading | pubmed-meshheading:12096037... | lld:pubmed |
| pubmed-article:12096037 | pubmed:meshHeading | pubmed-meshheading:12096037... | lld:pubmed |
| pubmed-article:12096037 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12096037 | pubmed:articleTitle | The assembly of functional beta(2)-microglobulin-free MHC class I molecules that interact with peptides and CD8(+) T lymphocytes. | lld:pubmed |
| pubmed-article:12096037 | pubmed:affiliation | Department of Microbiology and Immunology, Pennsylvania State University, College of Medicine, Hershey, PA 17033, USA. | lld:pubmed |
| pubmed-article:12096037 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12096037 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12096037 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12096037 | lld:pubmed |
