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pubmed-article:12093373pubmed:abstractTextSomatic cell mutants can be informative in the analysis of a wide variety of cellular processes. The use of map-based positional cloning strategies in somatic cell hybrids to analyze genes responsible for recessive mutant phenotypes is often tedious, however, and remains a major obstacle in somatic cell genetics. To fulfill the need for more efficient gene mapping in somatic cell mutants, we have developed a new DNA microarray comparative genomic hybridization (array-CGH) method that can rapidly and efficiently map the physical location of genes complementing somatic cell mutants to a small candidate genomic region. Here we report experiments that establish the validity and efficacy of the methodology.lld:pubmed
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pubmed-article:12093373pubmed:dateRevised2009-11-18lld:pubmed
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pubmed-article:12093373pubmed:year2002lld:pubmed
pubmed-article:12093373pubmed:articleTitlePhysical mapping of genes in somatic cell radiation hybrids by comparative genomic hybridization to cDNA microarrays.lld:pubmed
pubmed-article:12093373pubmed:affiliationDepartment of Vascular Biology, The Scripps Research Institute, 10550 N, Torrey Pines Road, La Jolla, CA 92037, USA. Ginsberg@scripps.edulld:pubmed
pubmed-article:12093373pubmed:publicationTypeJournal Articlelld:pubmed
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