| pubmed-article:12092847 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12092847 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:12092847 | lifeskim:mentions | umls-concept:C0037993 | lld:lifeskim |
| pubmed-article:12092847 | lifeskim:mentions | umls-concept:C0031272 | lld:lifeskim |
| pubmed-article:12092847 | lifeskim:mentions | umls-concept:C0003320 | lld:lifeskim |
| pubmed-article:12092847 | lifeskim:mentions | umls-concept:C0206431 | lld:lifeskim |
| pubmed-article:12092847 | lifeskim:mentions | umls-concept:C0079189 | lld:lifeskim |
| pubmed-article:12092847 | lifeskim:mentions | umls-concept:C0178602 | lld:lifeskim |
| pubmed-article:12092847 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:12092847 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:12092847 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:12092847 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:12092847 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:12092847 | lifeskim:mentions | umls-concept:C0449774 | lld:lifeskim |
| pubmed-article:12092847 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:12092847 | pubmed:dateCreated | 2002-7-2 | lld:pubmed |
| pubmed-article:12092847 | pubmed:abstractText | The Th1 and Th2 preference induced by cells from the Peyer's patch (PP) and spleen (SPL) with various doses of an antigen was examined. The same splenic T cell receptor-transgenic CD4+ T cells were first incubated with PP or SPL cells in the presence of various doses of an antigen, and the cytokine response was observed after secondary stimulation. A Th2-type pattern was only obtained for primary stimulation at 10 microM of the antigen with PP cells, whereas a Th1 pattern was induced at both higher and lower concentrations. SPL cells in the presence of 0.1 to 1 microM of the antigen induced the secretion of Th2-type cytokines. Ten and 100 microM of the antigen plus SPL cells did not induce the release of a large quantity of cytokines. PP cells induced a different cytokine pattern at the antigen concentration that induced a similar level of T cell proliferation with SPL cells. Our findings suggest that the antigen-dose dependent development of Th1/Th2 cells is differentially modulated by the antigen-presentation function of cells in PP and SPL. | lld:pubmed |
| pubmed-article:12092847 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12092847 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12092847 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12092847 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12092847 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12092847 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12092847 | pubmed:month | May | lld:pubmed |
| pubmed-article:12092847 | pubmed:issn | 0916-8451 | lld:pubmed |
| pubmed-article:12092847 | pubmed:author | pubmed-author:HachimuraSato... | lld:pubmed |
| pubmed-article:12092847 | pubmed:author | pubmed-author:KaminogawaShu... | lld:pubmed |
| pubmed-article:12092847 | pubmed:author | pubmed-author:YoshidaTadash... | lld:pubmed |
| pubmed-article:12092847 | pubmed:author | pubmed-author:IseWataruW | lld:pubmed |
| pubmed-article:12092847 | pubmed:author | pubmed-author:TotsukaMamoru... | lld:pubmed |
| pubmed-article:12092847 | pubmed:author | pubmed-author:AmetaniAkioA | lld:pubmed |
| pubmed-article:12092847 | pubmed:author | pubmed-author:IshimoriMinaM | lld:pubmed |
| pubmed-article:12092847 | pubmed:author | pubmed-author:KinugasaFumit... | lld:pubmed |
| pubmed-article:12092847 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12092847 | pubmed:volume | 66 | lld:pubmed |
| pubmed-article:12092847 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12092847 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12092847 | pubmed:pagination | 963-9 | lld:pubmed |
| pubmed-article:12092847 | pubmed:dateRevised | 2003-11-14 | lld:pubmed |
| pubmed-article:12092847 | pubmed:meshHeading | pubmed-meshheading:12092847... | lld:pubmed |
| pubmed-article:12092847 | pubmed:meshHeading | pubmed-meshheading:12092847... | lld:pubmed |
| pubmed-article:12092847 | pubmed:meshHeading | pubmed-meshheading:12092847... | lld:pubmed |
| pubmed-article:12092847 | pubmed:meshHeading | pubmed-meshheading:12092847... | lld:pubmed |
| pubmed-article:12092847 | pubmed:meshHeading | pubmed-meshheading:12092847... | lld:pubmed |
| pubmed-article:12092847 | pubmed:meshHeading | pubmed-meshheading:12092847... | lld:pubmed |
| pubmed-article:12092847 | pubmed:meshHeading | pubmed-meshheading:12092847... | lld:pubmed |
| pubmed-article:12092847 | pubmed:meshHeading | pubmed-meshheading:12092847... | lld:pubmed |
| pubmed-article:12092847 | pubmed:meshHeading | pubmed-meshheading:12092847... | lld:pubmed |
| pubmed-article:12092847 | pubmed:meshHeading | pubmed-meshheading:12092847... | lld:pubmed |
| pubmed-article:12092847 | pubmed:meshHeading | pubmed-meshheading:12092847... | lld:pubmed |
| pubmed-article:12092847 | pubmed:meshHeading | pubmed-meshheading:12092847... | lld:pubmed |
| pubmed-article:12092847 | pubmed:meshHeading | pubmed-meshheading:12092847... | lld:pubmed |
| pubmed-article:12092847 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12092847 | pubmed:articleTitle | Antigen presentation by Peyer's patch cells can induce both Th1- and Th2-type responses depending on antigen dosage, but a different cytokine response pattern from that of spleen cells. | lld:pubmed |
| pubmed-article:12092847 | pubmed:affiliation | Department of Applied Biological Chemistry, University of Tokyo, Japan. | lld:pubmed |
| pubmed-article:12092847 | pubmed:publicationType | Journal Article | lld:pubmed |
