| pubmed-article:12091396 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12091396 | lifeskim:mentions | umls-concept:C0330390 | lld:lifeskim |
| pubmed-article:12091396 | lifeskim:mentions | umls-concept:C0018296 | lld:lifeskim |
| pubmed-article:12091396 | lifeskim:mentions | umls-concept:C1426113 | lld:lifeskim |
| pubmed-article:12091396 | lifeskim:mentions | umls-concept:C1154393 | lld:lifeskim |
| pubmed-article:12091396 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:12091396 | lifeskim:mentions | umls-concept:C0070750 | lld:lifeskim |
| pubmed-article:12091396 | pubmed:issue | 43 | lld:pubmed |
| pubmed-article:12091396 | pubmed:dateCreated | 2002-10-25 | lld:pubmed |
| pubmed-article:12091396 | pubmed:abstractText | Leukocyte migration from bloodstream to tissue requires rapid, coordinated regulation of integrin-dependent adhesion and de-adhesion. In a previous study we demonstrated that inhibition of protein geranylgeranylation inhibited phorbol ester-stimulated avidity modulation of beta(1) integrin in several leukocyte cell lines. Both RhoA and Rap1 require post-translational modification by geranylgeranylation for full function. In this report we identify Rap1, not RhoA, as a critical geranylgeranylated protein mediating phorbol ester-stimulated beta(1) and beta(2) integrin-dependent adhesion of Jurkat cells. Overexpression of the Rap1-specific GTPase-activating protein, SPA-1, or inactivated form of Rap1 (N17Rap1) blocked phorbol ester-stimulated adhesion of Jurkat cells to fibronectin (alpha(4)beta(1)) and ICAM-1 (alpha(L)beta(2)). With high concentrations of fibronectin as ligand, Jurkat cells adhered spontaneously without phorbol ester stimulation. Unlike the phorbol ester-stimulated adhesion, adhesion induced by high density ligand was not dependent upon Rap1 activation or actin cytoskeleton reorganization. Thus, the "inside-out" adhesion signal induced by phorbol ester and the "outside-in" signal induced by high density ligand involve different pathways. | lld:pubmed |
| pubmed-article:12091396 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12091396 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12091396 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12091396 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12091396 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12091396 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12091396 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:12091396 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:12091396 | pubmed:author | pubmed-author:JosKK | lld:pubmed |
| pubmed-article:12091396 | pubmed:author | pubmed-author:WinnRobert... | lld:pubmed |
| pubmed-article:12091396 | pubmed:author | pubmed-author:HarlanJohn... | lld:pubmed |
| pubmed-article:12091396 | pubmed:author | pubmed-author:LinNancyN | lld:pubmed |
| pubmed-article:12091396 | pubmed:author | pubmed-author:SchwartzBarba... | lld:pubmed |
| pubmed-article:12091396 | pubmed:author | pubmed-author:TupperJoanJ | lld:pubmed |
| pubmed-article:12091396 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12091396 | pubmed:day | 25 | lld:pubmed |
| pubmed-article:12091396 | pubmed:volume | 277 | lld:pubmed |
| pubmed-article:12091396 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12091396 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12091396 | pubmed:pagination | 40893-900 | lld:pubmed |
| pubmed-article:12091396 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:12091396 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12091396 | pubmed:articleTitle | The GTPase Rap1 regulates phorbol 12-myristate 13-acetate-stimulated but not ligand-induced beta 1 integrin-dependent leukocyte adhesion. | lld:pubmed |
| pubmed-article:12091396 | pubmed:affiliation | Department of Medicine, Division of Hematology, University of Washington, Seattle, WA 98104, USA. liliu@u.washington.edu | lld:pubmed |
| pubmed-article:12091396 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12091396 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12091396 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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