| pubmed-article:12086861 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12086861 | lifeskim:mentions | umls-concept:C0694897 | lld:lifeskim |
| pubmed-article:12086861 | lifeskim:mentions | umls-concept:C0007134 | lld:lifeskim |
| pubmed-article:12086861 | lifeskim:mentions | umls-concept:C0031437 | lld:lifeskim |
| pubmed-article:12086861 | lifeskim:mentions | umls-concept:C1333897 | lld:lifeskim |
| pubmed-article:12086861 | lifeskim:mentions | umls-concept:C1704838 | lld:lifeskim |
| pubmed-article:12086861 | lifeskim:mentions | umls-concept:C1167622 | lld:lifeskim |
| pubmed-article:12086861 | lifeskim:mentions | umls-concept:C1710236 | lld:lifeskim |
| pubmed-article:12086861 | lifeskim:mentions | umls-concept:C1880177 | lld:lifeskim |
| pubmed-article:12086861 | lifeskim:mentions | umls-concept:C1517945 | lld:lifeskim |
| pubmed-article:12086861 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:12086861 | pubmed:dateCreated | 2002-6-27 | lld:pubmed |
| pubmed-article:12086861 | pubmed:abstractText | Clear-cell renal carcinoma is associated with inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene. VHL is the substrate recognition subunit of an E3 ligase, known to target the alpha subunits of the HIF heterodimeric transcription factor for ubiquitin-mediated degradation under normoxic conditions. We demonstrate that competitive inhibition of the VHL substrate recognition site with a peptide derived from the oxygen degradation domain of HIF1alpha recapitulates the tumorigenic phenotype of VHL-deficient tumor cells. These studies prove that VHL substrate recognition is essential to the tumor suppressor function of VHL. We further demonstrate that normoxic stabilization of HIF1alpha alone, while capable of mimicking some aspects of VHL loss, is not sufficient to reproduce tumorigenesis, indicating that it is not the critical oncogenic substrate of VHL. | lld:pubmed |
| pubmed-article:12086861 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086861 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12086861 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086861 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12086861 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086861 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086861 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086861 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086861 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086861 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086861 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086861 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086861 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086861 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086861 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086861 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086861 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086861 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086861 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12086861 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12086861 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:12086861 | pubmed:issn | 1535-6108 | lld:pubmed |
| pubmed-article:12086861 | pubmed:author | pubmed-author:LinehanW... | lld:pubmed |
| pubmed-article:12086861 | pubmed:author | pubmed-author:BonifacinoJua... | lld:pubmed |
| pubmed-article:12086861 | pubmed:author | pubmed-author:KlausnerRicha... | lld:pubmed |
| pubmed-article:12086861 | pubmed:author | pubmed-author:VasselliJames... | lld:pubmed |
| pubmed-article:12086861 | pubmed:author | pubmed-author:MaranchieJodi... | lld:pubmed |
| pubmed-article:12086861 | pubmed:author | pubmed-author:RissJosephJ | lld:pubmed |
| pubmed-article:12086861 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12086861 | pubmed:volume | 1 | lld:pubmed |
| pubmed-article:12086861 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12086861 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12086861 | pubmed:pagination | 247-55 | lld:pubmed |
| pubmed-article:12086861 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:12086861 | pubmed:meshHeading | pubmed-meshheading:12086861... | lld:pubmed |
| pubmed-article:12086861 | pubmed:meshHeading | pubmed-meshheading:12086861... | lld:pubmed |
| pubmed-article:12086861 | pubmed:meshHeading | pubmed-meshheading:12086861... | lld:pubmed |
| pubmed-article:12086861 | pubmed:meshHeading | pubmed-meshheading:12086861... | lld:pubmed |
| pubmed-article:12086861 | pubmed:meshHeading | pubmed-meshheading:12086861... | lld:pubmed |
| pubmed-article:12086861 | pubmed:meshHeading | pubmed-meshheading:12086861... | lld:pubmed |
| pubmed-article:12086861 | pubmed:meshHeading | pubmed-meshheading:12086861... | lld:pubmed |
| pubmed-article:12086861 | pubmed:meshHeading | pubmed-meshheading:12086861... | lld:pubmed |
| pubmed-article:12086861 | pubmed:meshHeading | pubmed-meshheading:12086861... | lld:pubmed |
| pubmed-article:12086861 | pubmed:meshHeading | pubmed-meshheading:12086861... | lld:pubmed |
| pubmed-article:12086861 | pubmed:meshHeading | pubmed-meshheading:12086861... | lld:pubmed |
| pubmed-article:12086861 | pubmed:meshHeading | pubmed-meshheading:12086861... | lld:pubmed |
| pubmed-article:12086861 | pubmed:meshHeading | pubmed-meshheading:12086861... | lld:pubmed |
| pubmed-article:12086861 | pubmed:meshHeading | pubmed-meshheading:12086861... | lld:pubmed |
| pubmed-article:12086861 | pubmed:meshHeading | pubmed-meshheading:12086861... | lld:pubmed |
| pubmed-article:12086861 | pubmed:meshHeading | pubmed-meshheading:12086861... | lld:pubmed |
| pubmed-article:12086861 | pubmed:meshHeading | pubmed-meshheading:12086861... | lld:pubmed |
| pubmed-article:12086861 | pubmed:meshHeading | pubmed-meshheading:12086861... | lld:pubmed |
| pubmed-article:12086861 | pubmed:meshHeading | pubmed-meshheading:12086861... | lld:pubmed |
| pubmed-article:12086861 | pubmed:meshHeading | pubmed-meshheading:12086861... | lld:pubmed |
| pubmed-article:12086861 | pubmed:meshHeading | pubmed-meshheading:12086861... | lld:pubmed |
| pubmed-article:12086861 | pubmed:meshHeading | pubmed-meshheading:12086861... | lld:pubmed |
| pubmed-article:12086861 | pubmed:meshHeading | pubmed-meshheading:12086861... | lld:pubmed |
| pubmed-article:12086861 | pubmed:meshHeading | pubmed-meshheading:12086861... | lld:pubmed |
| pubmed-article:12086861 | pubmed:meshHeading | pubmed-meshheading:12086861... | lld:pubmed |
| pubmed-article:12086861 | pubmed:meshHeading | pubmed-meshheading:12086861... | lld:pubmed |
| pubmed-article:12086861 | pubmed:meshHeading | pubmed-meshheading:12086861... | lld:pubmed |
| pubmed-article:12086861 | pubmed:meshHeading | pubmed-meshheading:12086861... | lld:pubmed |
| pubmed-article:12086861 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12086861 | pubmed:articleTitle | The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma. | lld:pubmed |
| pubmed-article:12086861 | pubmed:affiliation | Urologic Oncology Branch, National Institutes of Health, Bethesda, MD 20892, USA. | lld:pubmed |
| pubmed-article:12086861 | pubmed:publicationType | Journal Article | lld:pubmed |
| entrez-gene:3091 | entrezgene:pubmed | pubmed-article:12086861 | lld:entrezgene |
| entrez-gene:7428 | entrezgene:pubmed | pubmed-article:12086861 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:12086861 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12086861 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12086861 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12086861 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12086861 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12086861 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12086861 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12086861 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12086861 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12086861 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12086861 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12086861 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12086861 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12086861 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12086861 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12086861 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12086861 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12086861 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12086861 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12086861 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12086861 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12086861 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12086861 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12086861 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12086861 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12086861 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12086861 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12086861 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12086861 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12086861 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12086861 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12086861 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12086861 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12086861 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12086861 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12086861 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12086861 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12086861 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12086861 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12086861 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12086861 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12086861 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12086861 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12086861 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12086861 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12086861 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12086861 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12086861 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12086861 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12086861 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12086861 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12086861 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12086861 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12086861 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12086861 | lld:pubmed |
