| pubmed-article:12085319 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12085319 | lifeskim:mentions | umls-concept:C0376526 | lld:lifeskim |
| pubmed-article:12085319 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:12085319 | lifeskim:mentions | umls-concept:C0036220 | lld:lifeskim |
| pubmed-article:12085319 | lifeskim:mentions | umls-concept:C0242656 | lld:lifeskim |
| pubmed-article:12085319 | lifeskim:mentions | umls-concept:C1261478 | lld:lifeskim |
| pubmed-article:12085319 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
| pubmed-article:12085319 | lifeskim:mentions | umls-concept:C0681842 | lld:lifeskim |
| pubmed-article:12085319 | lifeskim:mentions | umls-concept:C0205250 | lld:lifeskim |
| pubmed-article:12085319 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:12085319 | pubmed:dateCreated | 2002-6-26 | lld:pubmed |
| pubmed-article:12085319 | pubmed:abstractText | Kaposi's sarcoma-associated herpesvirus (KSHV) is found in Kaposi's sarcoma (KS), multicentric Castleman's disease, and primary effusion lymphomas. To prospectively evaluate KSHV load as a biomarker for KS clinical status and prognosis in a cohort of men with AIDS-related KS, 2 quantitative polymerase chain reaction (PCR) assays were developed and tested to determine KSHV peripheral blood mononuclear cell (PBMC) virus loads. Most patients (13/15) with good-prognosis KS had < or =1.5 log KSHV copies/10(5) PBMC by both quantitative competitive (QC) and real-time Applied Biosystems (ABI) PCR. Both assays provided 94% specificity for identifying the 16 patients without KS progression during 20 months of follow-up. QC-PCR and ABI-PCR exhibited 100% and 80% levels of diagnostic sensitivity, respectively, for identifying the 5 patients whose KS progressed. Neither dichotomized human immunodeficiency virus loads nor dichotomized CD4 counts predicted either KS progression or KS clinical stage (all positive predictive values < 30%). These results are evidence that the quantity of circulating KSHV in KS patients is biologically meaningful and is measurable with sufficient accuracy to provide clinically useful information. | lld:pubmed |
| pubmed-article:12085319 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12085319 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12085319 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12085319 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12085319 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12085319 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12085319 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:12085319 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12085319 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:12085319 | pubmed:issn | 0022-1899 | lld:pubmed |
| pubmed-article:12085319 | pubmed:author | pubmed-author:DavisMichelle... | lld:pubmed |
| pubmed-article:12085319 | pubmed:author | pubmed-author:StewartPaul... | lld:pubmed |
| pubmed-article:12085319 | pubmed:author | pubmed-author:QuinlivanE... | lld:pubmed |
| pubmed-article:12085319 | pubmed:author | pubmed-author:ZhangChuanC | lld:pubmed |
| pubmed-article:12085319 | pubmed:author | pubmed-author:KomoltriChula... | lld:pubmed |
| pubmed-article:12085319 | pubmed:author | pubmed-author:WehbieRobert... | lld:pubmed |
| pubmed-article:12085319 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12085319 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:12085319 | pubmed:volume | 185 | lld:pubmed |
| pubmed-article:12085319 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12085319 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12085319 | pubmed:pagination | 1736-44 | lld:pubmed |
| pubmed-article:12085319 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:12085319 | pubmed:meshHeading | pubmed-meshheading:12085319... | lld:pubmed |
| pubmed-article:12085319 | pubmed:meshHeading | pubmed-meshheading:12085319... | lld:pubmed |
| pubmed-article:12085319 | pubmed:meshHeading | pubmed-meshheading:12085319... | lld:pubmed |
| pubmed-article:12085319 | pubmed:meshHeading | pubmed-meshheading:12085319... | lld:pubmed |
| pubmed-article:12085319 | pubmed:meshHeading | pubmed-meshheading:12085319... | lld:pubmed |
| pubmed-article:12085319 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12085319 | pubmed:articleTitle | Elevated virus loads of Kaposi's sarcoma-associated human herpesvirus 8 predict Kaposi's sarcoma disease progression, but elevated levels of human immunodeficiency virus type 1 do not. | lld:pubmed |
| pubmed-article:12085319 | pubmed:affiliation | Department of Medicine, Lineberger Comprehensive Cancer Center, 547 Burnett-Womack Building, University of North Carolina, Chapel Hill, NC 27599, USA. ebq@med.unc.edu | lld:pubmed |
| pubmed-article:12085319 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12085319 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12085319 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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