| pubmed-article:12085207 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12085207 | lifeskim:mentions | umls-concept:C1516213 | lld:lifeskim |
| pubmed-article:12085207 | lifeskim:mentions | umls-concept:C0242643 | lld:lifeskim |
| pubmed-article:12085207 | lifeskim:mentions | umls-concept:C0024623 | lld:lifeskim |
| pubmed-article:12085207 | lifeskim:mentions | umls-concept:C0016360 | lld:lifeskim |
| pubmed-article:12085207 | lifeskim:mentions | umls-concept:C0040085 | lld:lifeskim |
| pubmed-article:12085207 | lifeskim:mentions | umls-concept:C0085533 | lld:lifeskim |
| pubmed-article:12085207 | lifeskim:mentions | umls-concept:C0728940 | lld:lifeskim |
| pubmed-article:12085207 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:12085207 | lifeskim:mentions | umls-concept:C1880198 | lld:lifeskim |
| pubmed-article:12085207 | lifeskim:mentions | umls-concept:C0332293 | lld:lifeskim |
| pubmed-article:12085207 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:12085207 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:12085207 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:12085207 | pubmed:dateCreated | 2002-6-26 | lld:pubmed |
| pubmed-article:12085207 | pubmed:abstractText | Both 5-fluorouracil and doxorubicin are commonly used agents in chemotherapy of gastric cancer in adjuvant setting as well as metastatic disease. In a variety of malignancies, high expression of multidrug resistance-associated protein1 and P-glycoprotein has been associated with resistance to doxorubicin, whereas 5-fluorouracil resistance has correlated with the level of thymidylate synthase expression. We evaluated the expression of multidrug resistance-associated protein1, P-glycoprotein, and thymidylate synthase using immunohistochemistry in 103 locally advanced gastric cancer patients (stage IB-IV) who underwent 5-fluorouracil and doxorubicin-based adjuvant chemotherapy after curative resection and investigated the association between their expression and clinicopathologic characteristics including prognosis of the patients. While high expression (> or =5% of tumour cells positive) of multidrug resistance-associated protein1 and P-glycoprotein was observed in 70 patients (68%) and 42 patients (41%), respectively, 65 patients (63%) had primary tumours with high expression (> or =25% of tumour cells positive) of thymidylate synthase. There was a significant association between multidrug resistance-associated protein1 and P-glycoprotein expression (P<0.0001) as well as P-glycoprotein and thymidylate synthase expression (P<0.0001). High multidrug resistance-associated protein1 and P-glycoprotein expressions were associated with well and moderately differentiated histology (P<0.0001 and P=0.03, respectively) and intestinal type (P<0.0001 and P=0.009, respectively). High multidrug resistance-associated protein1 expression correlated with lymph node metastasis (P=0.037), advanced stage (P=0.015), and older age (P=0.021). Five-year disease-free survival and overall survival of total patients were 55.2% and 56.2%, respectively, with a median follow-up of 68 months. There were no significant differences in disease-free survival and overall survival according to the expression of multidrug resistance-associated protein1 (P=0.902 and P=0.975, respectively), P-glycoprotein (P=0.987 and P=0.955, respectively), and thymidylate synthase (P=0.604 and P=0.802, respectively). Concurrent high expression of these proteins (high multidrug resistance-associated protein1/P-glycoprotein, high multidrug resistance-associated protein1/thymidylate synthase, high P-glycoprotein/thymidylate synthase) did not correlate with disease-free survival or overall survival. Even high expression of all three proteins was not associated with poor disease-free survival (P=0.919) and overall survival (P=0.852). In conclusion, high expression of multidrug resistance-associated protein1, P-glycoprotein, and thymidylate synthase did not predict poor prognosis of gastric cancer patients treated with 5-fluorouracil and doxorubicin-based adjuvant chemotherapy. A larger study including patients treated with surgical resection alone would be necessary. | lld:pubmed |
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| pubmed-article:12085207 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12085207 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12085207 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12085207 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12085207 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12085207 | pubmed:month | May | lld:pubmed |
| pubmed-article:12085207 | pubmed:issn | 0007-0920 | lld:pubmed |
| pubmed-article:12085207 | pubmed:author | pubmed-author:ChoY KYK | lld:pubmed |
| pubmed-article:12085207 | pubmed:author | pubmed-author:KimH SHS | lld:pubmed |
| pubmed-article:12085207 | pubmed:author | pubmed-author:KimH CHC | lld:pubmed |
| pubmed-article:12085207 | pubmed:author | pubmed-author:EssTT | lld:pubmed |
| pubmed-article:12085207 | pubmed:author | pubmed-author:KuoJ SJS | lld:pubmed |
| pubmed-article:12085207 | pubmed:author | pubmed-author:KimM WMW | lld:pubmed |
| pubmed-article:12085207 | pubmed:author | pubmed-author:LeeK BKB | lld:pubmed |
| pubmed-article:12085207 | pubmed:author | pubmed-author:KwaI HIH | lld:pubmed |
| pubmed-article:12085207 | pubmed:author | pubmed-author:ChoiJ-HJH | lld:pubmed |
| pubmed-article:12085207 | pubmed:copyrightInfo | comCopyright 2002 Cancer Research UK | lld:pubmed |
| pubmed-article:12085207 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12085207 | pubmed:day | 20 | lld:pubmed |
| pubmed-article:12085207 | pubmed:volume | 86 | lld:pubmed |
| pubmed-article:12085207 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12085207 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12085207 | pubmed:pagination | 1578-85 | lld:pubmed |
| pubmed-article:12085207 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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