| pubmed-article:12080470 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12080470 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:12080470 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:12080470 | lifeskim:mentions | umls-concept:C0040648 | lld:lifeskim |
| pubmed-article:12080470 | lifeskim:mentions | umls-concept:C0041904 | lld:lifeskim |
| pubmed-article:12080470 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:12080470 | pubmed:issue | 28 | lld:pubmed |
| pubmed-article:12080470 | pubmed:dateCreated | 2002-6-24 | lld:pubmed |
| pubmed-article:12080470 | pubmed:abstractText | Rel/NF-kappaB transcription factors are involved in several physiological processes, including the regulation of apoptosis. These factors were shown to exhibit pro- or anti-apoptotic activities in different cellular models, but at present, the mechanisms underlying these opposite effects are poorly understood. In this study, we show that the constitutive expression of a transcriptionally active member of the Rel/NF-kappaB family, c-Rel, first induces a resistance against TNFalpha-induced apoptosis and later increases the level of spontaneous apoptosis of HeLa cells. Both the anti- and pro-apoptotic effects increase with the level of c-Rel overexpression. The up-regulation by c-Rel of the manganese superoxide dismutase (MnSOD) could explain both the rapid anti-apoptotic effect and the delayed pro-apoptotic one. Indeed, the enzymatic activity of MnSOD is to transform the toxic O(2)(*)(-) in H(2)O(2). Hence, on one hand, its induction helps cells to resist against the apoptogenic burst of O(2)(*)(-) produced upon TNFalpha stimulation, but on the other hand, it leads to a progressive H(2)O(2) accumulation that ultimately results in apoptosis. These results indicate that the anti- and pro-apoptotic effects of Rel/NF-kappaB factors are not necessarily alternative but can occur successively in the same cell, via the up-regulation of the same target gene. | lld:pubmed |
| pubmed-article:12080470 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:12080470 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12080470 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12080470 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:12080470 | pubmed:issn | 0950-9232 | lld:pubmed |
| pubmed-article:12080470 | pubmed:author | pubmed-author:BernardDavidD | lld:pubmed |
| pubmed-article:12080470 | pubmed:author | pubmed-author:VandenbunderB... | lld:pubmed |
| pubmed-article:12080470 | pubmed:author | pubmed-author:MonteDidierD | lld:pubmed |
| pubmed-article:12080470 | pubmed:author | pubmed-author:AbbadieCorinn... | lld:pubmed |
| pubmed-article:12080470 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12080470 | pubmed:day | 27 | lld:pubmed |
| pubmed-article:12080470 | pubmed:volume | 21 | lld:pubmed |
| pubmed-article:12080470 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12080470 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12080470 | pubmed:pagination | 4392-402 | lld:pubmed |
| pubmed-article:12080470 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:12080470 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12080470 | pubmed:articleTitle | The c-Rel transcription factor can both induce and inhibit apoptosis in the same cells via the upregulation of MnSOD. | lld:pubmed |
| pubmed-article:12080470 | pubmed:affiliation | FRE 2353 CNRS/Institut Pasteur de Lille/Université Lille 2, Institut de Biologie de Lille, 1 rue Calmette, 59021 Lille Cedex, France. | lld:pubmed |
| pubmed-article:12080470 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12080470 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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