| pubmed-article:12075355 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12075355 | lifeskim:mentions | umls-concept:C0037274 | lld:lifeskim |
| pubmed-article:12075355 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:12075355 | lifeskim:mentions | umls-concept:C0333348 | lld:lifeskim |
| pubmed-article:12075355 | lifeskim:mentions | umls-concept:C1442161 | lld:lifeskim |
| pubmed-article:12075355 | lifeskim:mentions | umls-concept:C1442489 | lld:lifeskim |
| pubmed-article:12075355 | pubmed:issue | 6891 | lld:pubmed |
| pubmed-article:12075355 | pubmed:dateCreated | 2002-6-20 | lld:pubmed |
| pubmed-article:12075355 | pubmed:abstractText | The I kappa B kinase (IKK), consisting of the IKK1 and IKK2 catalytic subunits and the NEMO (also known as IKK gamma) regulatory subunit, phosphorylates I kappa B proteins, targeting them for degradation and thus inducing activation of NF-kappa B (reviewed in refs 1, 2). IKK2 and NEMO are necessary for NF-kappa B activation through pro-inflammatory signals. IKK1 seems to be dispensable for this function but controls epidermal differentiation independently of NF-kappa B. Previous studies suggested that NF-kappa B has a function in the growth regulation of epidermal keratinocytes. Mice lacking RelB or I kappa B alpha, as well as both mice and humans with heterozygous NEMO mutations, develop skin lesions. However, the function of NF-kappa B in the epidermis remains unclear. Here we used Cre/loxP-mediated gene targeting to investigate the function of IKK2 specifically in epidermal keratinocytes. IKK2 deficiency inhibits NF-kappa B activation, but does not lead to cell-autonomous hyperproliferation or impaired differentiation of keratinocytes. Mice with epidermis-specific deletion of IKK2 develop a severe inflammatory skin disease, which is caused by a tumour necrosis factor-mediated, alpha beta T-cell-independent inflammatory response that develops in the skin shortly after birth. Our results suggest that the critical function of IKK2-mediated NF-kappa B activity in epidermal keratinocytes is to regulate mechanisms that maintain the immune homeostasis of the skin. | lld:pubmed |
| pubmed-article:12075355 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12075355 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12075355 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12075355 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12075355 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12075355 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12075355 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:12075355 | pubmed:issn | 0028-0836 | lld:pubmed |
| pubmed-article:12075355 | pubmed:author | pubmed-author:KriegThomasT | lld:pubmed |
| pubmed-article:12075355 | pubmed:author | pubmed-author:HafnerMartinM | lld:pubmed |
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| pubmed-article:12075355 | pubmed:author | pubmed-author:RajewskyKlaus... | lld:pubmed |
| pubmed-article:12075355 | pubmed:author | pubmed-author:NenciAriannaA | lld:pubmed |
| pubmed-article:12075355 | pubmed:author | pubmed-author:HaaseIngoI | lld:pubmed |
| pubmed-article:12075355 | pubmed:author | pubmed-author:GoebelerMatth... | lld:pubmed |
| pubmed-article:12075355 | pubmed:author | pubmed-author:GillitzerRein... | lld:pubmed |
| pubmed-article:12075355 | pubmed:author | pubmed-author:IsraelAlainA | lld:pubmed |
| pubmed-article:12075355 | pubmed:author | pubmed-author:PasparakisMan... | lld:pubmed |
| pubmed-article:12075355 | pubmed:author | pubmed-author:Schmidt-Suppr... | lld:pubmed |
| pubmed-article:12075355 | pubmed:author | pubmed-author:ToksoyAtiyeA | lld:pubmed |
| pubmed-article:12075355 | pubmed:author | pubmed-author:KrampertMonik... | lld:pubmed |
| pubmed-article:12075355 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12075355 | pubmed:day | 20 | lld:pubmed |
| pubmed-article:12075355 | pubmed:volume | 417 | lld:pubmed |
| pubmed-article:12075355 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12075355 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12075355 | pubmed:pagination | 861-6 | lld:pubmed |
| pubmed-article:12075355 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:12075355 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12075355 | pubmed:articleTitle | TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2. | lld:pubmed |
| pubmed-article:12075355 | pubmed:affiliation | Institute for Genetics, University of Cologne, Weyertal 121, D-50931 Cologne, Germany. pasparakis@embl-monterotondo.it | lld:pubmed |
| pubmed-article:12075355 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12075355 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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