| pubmed-article:12070281 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12070281 | lifeskim:mentions | umls-concept:C0025260 | lld:lifeskim |
| pubmed-article:12070281 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
| pubmed-article:12070281 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
| pubmed-article:12070281 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:12070281 | lifeskim:mentions | umls-concept:C0021764 | lld:lifeskim |
| pubmed-article:12070281 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
| pubmed-article:12070281 | lifeskim:mentions | umls-concept:C1514559 | lld:lifeskim |
| pubmed-article:12070281 | lifeskim:mentions | umls-concept:C0031437 | lld:lifeskim |
| pubmed-article:12070281 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
| pubmed-article:12070281 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
| pubmed-article:12070281 | lifeskim:mentions | umls-concept:C0181586 | lld:lifeskim |
| pubmed-article:12070281 | lifeskim:mentions | umls-concept:C0079411 | lld:lifeskim |
| pubmed-article:12070281 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:12070281 | pubmed:dateCreated | 2002-6-18 | lld:pubmed |
| pubmed-article:12070281 | pubmed:abstractText | Transgenic (TG) mice expressing a high copy number of interleukin (IL)-7 cDNA under the control of the major histocomaptability complex (MHC) class II promoter display a 10-20-fold increase in total T cell numbers. Here, we show that the increase in T cell numbers in IL-7 TG mice is most apparent at the level of memory phenotype CD44hi CD122hi CD8+ cells. Based on studies with T cell receptor (TCR) TG mice crossed to IL-7 TG mice, increased levels of IL-7 may provide costimulation for TCR recognition of self-MHC ligands and thus cause naive CD8+ cells to proliferate and differentiate into memory phenotype cells. In addition, a marked increase in CD44hi CD122hi CD8+ cells was found in IL-7 TG IL-15(-) mice. Since these cell are rare in normal IL-15(-) mice, the dependency of memory phenotype CD8+ cells on IL-15 can be overcome by overexpression of IL-7. | lld:pubmed |
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| pubmed-article:12070281 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12070281 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12070281 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12070281 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12070281 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:12070281 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:12070281 | pubmed:author | pubmed-author:CeredigRhodri... | lld:pubmed |
| pubmed-article:12070281 | pubmed:author | pubmed-author:SurhCharles... | lld:pubmed |
| pubmed-article:12070281 | pubmed:author | pubmed-author:SprentJonatha... | lld:pubmed |
| pubmed-article:12070281 | pubmed:author | pubmed-author:GapinLaurentL | lld:pubmed |
| pubmed-article:12070281 | pubmed:author | pubmed-author:TanJoyce TJT | lld:pubmed |
| pubmed-article:12070281 | pubmed:author | pubmed-author:KieperWilliam... | lld:pubmed |
| pubmed-article:12070281 | pubmed:author | pubmed-author:Bondi-BoydBre... | lld:pubmed |
| pubmed-article:12070281 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12070281 | pubmed:day | 17 | lld:pubmed |
| pubmed-article:12070281 | pubmed:volume | 195 | lld:pubmed |
| pubmed-article:12070281 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12070281 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12070281 | pubmed:pagination | 1533-9 | lld:pubmed |
| pubmed-article:12070281 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:12070281 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12070281 | pubmed:articleTitle | Overexpression of interleukin (IL)-7 leads to IL-15-independent generation of memory phenotype CD8+ T cells. | lld:pubmed |
| pubmed-article:12070281 | pubmed:affiliation | Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA. | lld:pubmed |
| pubmed-article:12070281 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12070281 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12070281 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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