| pubmed-article:12065768 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12065768 | lifeskim:mentions | umls-concept:C0282552 | lld:lifeskim |
| pubmed-article:12065768 | lifeskim:mentions | umls-concept:C0333348 | lld:lifeskim |
| pubmed-article:12065768 | lifeskim:mentions | umls-concept:C0312861 | lld:lifeskim |
| pubmed-article:12065768 | lifeskim:mentions | umls-concept:C0678594 | lld:lifeskim |
| pubmed-article:12065768 | lifeskim:mentions | umls-concept:C1710548 | lld:lifeskim |
| pubmed-article:12065768 | lifeskim:mentions | umls-concept:C0127400 | lld:lifeskim |
| pubmed-article:12065768 | lifeskim:mentions | umls-concept:C0871161 | lld:lifeskim |
| pubmed-article:12065768 | lifeskim:mentions | umls-concept:C0971580 | lld:lifeskim |
| pubmed-article:12065768 | lifeskim:mentions | umls-concept:C1363844 | lld:lifeskim |
| pubmed-article:12065768 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:12065768 | pubmed:dateCreated | 2002-6-14 | lld:pubmed |
| pubmed-article:12065768 | pubmed:abstractText | The recently discovered CC chemokine, regakine-1, is constitutively present in bovine serum and synergizes with the CXC chemokine interleukin-8 (IL-8) to chemoattract neutrophils. Here we show that regakine-1 cooperates with the CXC chemokine receptor 2 ligand neutrophil activating protein-2 (NAP-2) and the anaphylatoxin C5a, two other mediators of inflammation present in the circulation. Neutrophil chemotaxis was 3-fold enhanced when regakine-1 (100 ng/ml) and C5a (30 ng/ml) were combined at concentrations present in bovine or human plasma, respectively. This synergy was also observed when neutrophils were preincubated with regakine-1. Plasma chemokines such as NAP-2, beta-thromboglobulin, and hemofiltrate CC-chemokine-1 did not affect C5a chemotactic activity. The capability of regakine-1 to synergize with C5a, NAP-2, or N-formyl-methionyl-leucyl-phenylalanine (fMLP) was not observed for monocyte chemotactic protein-3 (MCP-3), another CC chemokine that weakly chemoattracts neutrophils. Regakine-1 also failed to cooperate with MCP-3 and macrophage inflammatory protein-1alpha in neutrophil chemotaxis. The receptor of regakine-1 is not known yet. Competition with labeled fMLP or C5a for binding to neutrophils or receptor transfected cell lines demonstrated that regakine-1 did not alter receptor recognition. The protein kinase inhibitors 2'-amino-3'-methoxyflavone (PD98059), wortmannin and staurosporin had no effect on the synergy between C5a and regakine-1. Although NH2-terminal truncation affects the chemotactic potency of most chemokines, it did not affect the synergistic capacity of regakine-1 with C5a on neutrophils. These findings indicate that the constitutive plasma chemokine regakine-1 is a stable enhancer of the inflammatory response and that its blockade might be beneficial in acute and systemic inflammatory disorders. | lld:pubmed |
| pubmed-article:12065768 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12065768 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12065768 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12065768 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12065768 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12065768 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12065768 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12065768 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12065768 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12065768 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12065768 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12065768 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12065768 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12065768 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12065768 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12065768 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12065768 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12065768 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12065768 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12065768 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12065768 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:12065768 | pubmed:issn | 0026-895X | lld:pubmed |
| pubmed-article:12065768 | pubmed:author | pubmed-author:ProostPaulP | lld:pubmed |
| pubmed-article:12065768 | pubmed:author | pubmed-author:Van DammeJoJ | lld:pubmed |
| pubmed-article:12065768 | pubmed:author | pubmed-author:StruyfSofieS | lld:pubmed |
| pubmed-article:12065768 | pubmed:author | pubmed-author:GouwyMiekeM | lld:pubmed |
| pubmed-article:12065768 | pubmed:author | pubmed-author:MahieuFrankF | lld:pubmed |
| pubmed-article:12065768 | pubmed:author | pubmed-author:PutWillyW | lld:pubmed |
| pubmed-article:12065768 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12065768 | pubmed:volume | 62 | lld:pubmed |
| pubmed-article:12065768 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12065768 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12065768 | pubmed:pagination | 173-80 | lld:pubmed |
| pubmed-article:12065768 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:12065768 | pubmed:meshHeading | pubmed-meshheading:12065768... | lld:pubmed |
| pubmed-article:12065768 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12065768 | pubmed:articleTitle | The unique property of the CC chemokine regakine-1 to synergize with other plasma-derived inflammatory mediators in neutrophil chemotaxis does not reside in its NH2-terminal structure. | lld:pubmed |
| pubmed-article:12065768 | pubmed:affiliation | Laboratory of Molecular Immunology, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium. | lld:pubmed |
| pubmed-article:12065768 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12065768 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:12065768 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12065768 | lld:pubmed |
