Linked Life Data

12065529

Source:http://linkedlifedata.com/resource/pubmed/id/12065529

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:12065529rdf:typepubmed:Citationlld:pubmed
pubmed-article:12065529lifeskim:mentionsumls-concept:C0007452lld:lifeskim
pubmed-article:12065529lifeskim:mentionsumls-concept:C0439849lld:lifeskim
pubmed-article:12065529lifeskim:mentionsumls-concept:C0039194lld:lifeskim
pubmed-article:12065529lifeskim:mentionsumls-concept:C0030524lld:lifeskim
pubmed-article:12065529lifeskim:mentionsumls-concept:C0542341lld:lifeskim
pubmed-article:12065529lifeskim:mentionsumls-concept:C0205276lld:lifeskim
pubmed-article:12065529lifeskim:mentionsumls-concept:C0332281lld:lifeskim
pubmed-article:12065529lifeskim:mentionsumls-concept:C1332714lld:lifeskim
pubmed-article:12065529lifeskim:mentionsumls-concept:C0205217lld:lifeskim
pubmed-article:12065529lifeskim:mentionsumls-concept:C0205329lld:lifeskim
pubmed-article:12065529lifeskim:mentionsumls-concept:C1823153lld:lifeskim
pubmed-article:12065529lifeskim:mentionsumls-concept:C0392747lld:lifeskim
pubmed-article:12065529lifeskim:mentionsumls-concept:C0376249lld:lifeskim
pubmed-article:12065529lifeskim:mentionsumls-concept:C0445223lld:lifeskim
pubmed-article:12065529lifeskim:mentionsumls-concept:C1705241lld:lifeskim
pubmed-article:12065529lifeskim:mentionsumls-concept:C0439097lld:lifeskim
pubmed-article:12065529lifeskim:mentionsumls-concept:C2349976lld:lifeskim
pubmed-article:12065529lifeskim:mentionsumls-concept:C1552644lld:lifeskim
pubmed-article:12065529lifeskim:mentionsumls-concept:C1552599lld:lifeskim
pubmed-article:12065529lifeskim:mentionsumls-concept:C0443172lld:lifeskim
pubmed-article:12065529lifeskim:mentionsumls-concept:C1704787lld:lifeskim
pubmed-article:12065529lifeskim:mentionsumls-concept:C1547348lld:lifeskim
pubmed-article:12065529lifeskim:mentionsumls-concept:C1517945lld:lifeskim
pubmed-article:12065529pubmed:issue7lld:pubmed
pubmed-article:12065529pubmed:dateCreated2002-6-14lld:pubmed
pubmed-article:12065529pubmed:abstractTextBovine paratuberculosis is caused by the infection of young calves with Mycobacterium avium subsp. paratuberculosis, resulting in a chronic granulomatous infection of predominantly the ileum. After an incubation period of 2 to 5 years, the disease becomes progressive in some of the chronically infected, but asymptomatic cows. This results in a protein-losing enteropathy that will ultimately be fatal. A loss of cell-mediated immune responses in symptomatic animals has been described, but no information is available concerning immune reactivity in the intestine. We sought to investigate putative disease status-associated lymphocyte subset distributions and antigen-specific functional characteristics of mononuclear cells isolated from blood, gut-associated lymphoid tissue, and the intestinal walls of 22 cows in different stages of disease and in control animals. The results demonstrated a significant decrease in CD4(+) T-cell frequency and a significant increase in TcR1-N12(+) gamma delta T-cell frequency in ileum lamina propria lymphocytes of symptomatic animals compared to the asymptomatic shedders. Immunohistology revealed that there was also an absolute decrease in the number of CD4(+) T cells in sections of the lesional ileum. Our findings also indicated that both peripheral and intestinal cell-mediated responses are decreased in symptomatic animals compared to asymptomatic animals. We conclude that the decrease in cell-mediated responses is likely related to a loss of antigen-specific CD4(+) T cells, which is most prominent in the lesional ileum from symptomatic animals, thus contributing to the progressive nature of bovine paratuberculosis.lld:pubmed
pubmed-article:12065529pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12065529pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12065529pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12065529pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12065529pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12065529pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12065529pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12065529pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12065529pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12065529pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12065529pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12065529pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12065529pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12065529pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12065529pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12065529pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12065529pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12065529pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12065529pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12065529pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12065529pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12065529pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12065529pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12065529pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12065529pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12065529pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12065529pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12065529pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12065529pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12065529pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12065529pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12065529pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12065529pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12065529pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12065529pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12065529pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12065529pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12065529pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12065529pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12065529pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12065529pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12065529pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12065529pubmed:languageenglld:pubmed
pubmed-article:12065529pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12065529pubmed:citationSubsetIMlld:pubmed
pubmed-article:12065529pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12065529pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12065529pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12065529pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12065529pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12065529pubmed:statusMEDLINElld:pubmed
pubmed-article:12065529pubmed:monthJullld:pubmed
pubmed-article:12065529pubmed:issn0019-9567lld:pubmed
pubmed-article:12065529pubmed:authorpubmed-author:JungMMlld:pubmed
pubmed-article:12065529pubmed:authorpubmed-author:MüllerKerstin...lld:pubmed
pubmed-article:12065529pubmed:authorpubmed-author:van...lld:pubmed
pubmed-article:12065529pubmed:authorpubmed-author:GruysErikElld:pubmed
pubmed-article:12065529pubmed:authorpubmed-author:KoetsAdAlld:pubmed
pubmed-article:12065529pubmed:authorpubmed-author:RuttenVictorVlld:pubmed
pubmed-article:12065529pubmed:authorpubmed-author:van MilFransFlld:pubmed
pubmed-article:12065529pubmed:authorpubmed-author:BakkerDouweDlld:pubmed
pubmed-article:12065529pubmed:issnTypePrintlld:pubmed
pubmed-article:12065529pubmed:volume70lld:pubmed
pubmed-article:12065529pubmed:ownerNLMlld:pubmed
pubmed-article:12065529pubmed:authorsCompleteYlld:pubmed
pubmed-article:12065529pubmed:pagination3856-64lld:pubmed
pubmed-article:12065529pubmed:dateRevised2009-11-18lld:pubmed
pubmed-article:12065529pubmed:meshHeadingpubmed-meshheading:12065529...lld:pubmed
pubmed-article:12065529pubmed:meshHeadingpubmed-meshheading:12065529...lld:pubmed
pubmed-article:12065529pubmed:meshHeadingpubmed-meshheading:12065529...lld:pubmed
pubmed-article:12065529pubmed:meshHeadingpubmed-meshheading:12065529...lld:pubmed
pubmed-article:12065529pubmed:meshHeadingpubmed-meshheading:12065529...lld:pubmed
pubmed-article:12065529pubmed:meshHeadingpubmed-meshheading:12065529...lld:pubmed
More...